With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.
N,N?-Diisopropylethylamine (25.6 mL, 147.0 mmol) was added to a solution of tetrahydro-2H-pyran-4-ol (CAS:2081-44-9, 10.0 g, 98.0 mmol) in dry DCM (160 mL) cooled at 0 C. The resulting mixture was stirred for 10 minutes under argon at 0 C. Then methanesulfonyl chloride (CAS:124-63-0, 8.72 mL, 112.7 mmol) was added, and the mixture was stirred at 0 C for 2 h. The reaction mixture was extracted with DCM and 0.5 M HCl. The organic fraction was washed with water, brine and saturated NaHCO3. The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to give the titled compound.
The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBVIE S.A.R.L.; GALAPAGOS NV; ALTENBACH, Robert, J.; COWART, Marlon, D.; DE MUNCK, Tom, Roger Lisette; DROPSIT MONTOVERT, Sebastien Jean, Jacques Cedric; GFESSER, Gregory, A.; KELGTERMANS, Hans; MARTINA, Sebastien, Laurent Xavier; VAN DER PLAS, Steven, Emiel; WANG, Xueqing; (300 pag.)WO2016/193812; (2016); A1;,
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