With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
at room temperature, 29b (0.281 g, 0.62 mmol) was dissolved in N,N-dimethylacetamide (4 mL)Intermediate 1 (0.243 g, 0.74 mmol) was added and the mixture was stirred at room temperature for 60 min. A solution of sodium tris (acetoxy) borohydride (0.288 g, 1.36 mmol) was added to the reaction solution at 0 C, and the mixture was gradually added to the reaction at room temperature for 3 hours. The reaction solution was cooled to 0 C, adjusted to pH 8 with water (20 mL) and aqueous ammonia (2 mL), extracted with dichloromethane (50 mL x 3). The organic phases were combined and washed with saturated brine solution (50 mL x 1) Dried over anhydrous magnesium sulfate, filtered, spin dried, and purified by silica gel column chromatography (dichloromethane / methanol (v / v) = 60: 1) to give 29c (0.210 g, 58% yield) as a white solid.
The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
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