With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.
Lambda^Lambda^-dimethylformamide (0.27 mL, 3.47 mmol) was added to a solution of tetrahydropyranyl-4-acetic acid (5.0 g, 34.7 mmol) and thionyl chloride (2.53 mL, 34.7 mmol) in DCM (200 mL) at 0 ¡ãC. After stirring 1 h at RT the solution was cooled to 0 ¡ãC. 7V-Ethyl-A sopropylpropan-2 -amine (15.14 mL, 87 mmol) was added, followed by 4- bromoaniline (5.97 g, 34.7 mmol) in 20 mL DCM were added slowly and the solution was stirred at 0 ¡ãC. After 1 h the reaction was diluted with saturated ammonium chloride and the organics were removed. Ethyl acetate was added and the layers were separated. The aqueous layer was extracted with EtOAc. The combined organic extracts were washed with water, saturated sodium chloride, and dried over sodium sulfate. The solution was filtered and concentrated in vacuo to give the crude material N-(4- bromophenyl)-2-(tetrahydro-2//-pyran-4-yl)acetamide as a tan solid.
85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; AMGEN INC.; PARAS, Nick A,; BROWN, James; CHENG, Yuan; HITCHCOCK, Stephen; JUDD, Ted; LOPEZ, Patricia; MINATTI, Ana Elena; NIXEY, Thomas; POWERS, Timothy; TEGLEY, Christopher M.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; WO2011/90911; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics