With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.
Tetrahydro-2/-/-pyran-4-carboxamide (2 g, 15.5 mmol) was suspended in dry THF (20 ml_) and Lawesson’s reagent (3.13 g, 7.75mmol) was added. After refluxing for 4 h the mixture was poured into a saturated NaHC03 aqueous solution (200 ml_) and then extracted with diethylether (4 x 100 ml_). The organic layer was dried over Na2S04 and evaporated to dryness, affording 1.2 g (54%) of the title compound.HPLC: Rt: min 2.791H NMR (401 MHz, DMSO-d6) delta ppm 9.37 (br. s., 1 H), 9.08 (br. s., 1 H), 3.87 (dd, J = 4.0, 11.0 Hz, 2 H), 3.37 -3.23 (m, 2 H), 2.78 – 2.67 (m, 1 H), 1.75 (dq, J = 4.5, 12.5 Hz, 2 H), 1.63 – 1.52 (m, 2 H)HRMS (ESI) calcd for Ci6HnNOS [M+H]+ 146.0634, found 146.0634.
The synthetic route of 344329-76-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; PULICI, Maurizio; TRAQUANDI, Gabriella; MARCHIONNI, Chiara; SCOLARO, Alessandra; COLOMBO, Nicoletta; WO2012/113774; (2012); A1;,
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