With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
Step-i: Synthesis of tert-butyl ((2R,3 S ,5R)-2-(2 ,5-difluorophenyl)-5-(7- (methylsulfonyl)-2,7-diazaspiro [4.4] nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamateUnder inert atmosphere ((2R,3 S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate (Intermediate-I; 250mg) and 2-(methylsulfonyl)-2,7-diazaspiro[4.4] nonane (substituent-R2 172mg) were dissolved in anhydrous MeOH, Decaborane (28mg) was added to this reaction mixture at 25-30 C and stirred for 1 5h. MeOH was removed from the reaction mixture and residue obtained was purified by column chromatography using 0 to 2% MeOH in DCM as an eluent system to get thetitle compound as a white solid (264mg, 67% yield).
As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.
Reference£º
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit, C.; BAHEKAR, Rajesh; JADAV, Pradip; GOSWAMI, Amitgiri; PATEL, Pankaj; WO2014/61031; (2014); A1;,
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