Analyzing the synthesis route of 14774-36-8

As the paragraph descriping shows that 14774-36-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-36-8,(Tetrahydropyran-3-yl)methanol,as a common compound, the synthetic route is as follows.

Step 1 : To a solution of (tetrahydro-2H-pyran-3-yl)methanol (300 mg, 2.58 mmol) and TEA (522 mg, 5.17mmol) in dichloromethane (10 ml_) was added methanesulfonyl chloride (355 mg, 3.10 mmol) at 0 C and the reaction was allowed to warm to 20 C and stirred for 1 hour. The solution was washed with sat. aq. NaHCO3 (2 ml_), H2O (3×2 ml_), brine (1 ml_), dried and concentrated to give (tetrahydro-2H-pyran-3-yl)methyl methanesulfonate (500 mg), which was used in the next step directly

As the paragraph descriping shows that 14774-36-8 is playing an increasingly important role.

Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; JESSING, Mikkel; (126 pag.)WO2016/55618; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics