Brief introduction of 25850-22-0

The synthetic route of 25850-22-0 has been constantly updated, and we look forward to future research findings.

25850-22-0, 2,2-Dimethyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Benzyloxymethyl isoxazole-3-carboxylic acid (0.24 g, 1.0 mmol), 4-amino-2,2-dimethyltetrahydropyran (0.18 ml, 1.2 mmol) And 1-hydroxybenzotriazole (0.01 g, 0.1 mmol) Was added to chloroform (amylene added product) (2.5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.24 g, 1.2 mmol) was added at room temperature, After stirring overnight, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was passed through a short column of silica gel to remove impurities, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (2,2-dimethyltetrahydropyran-4-yl) -5-benzyloxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (335)) 0.29 g was obtained.

The synthetic route of 25850-22-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics