With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.
To a stirred solution of 2H-pyran-3,5(4H, 6H) -dione (0.7 g, 6.14 mmol) in 31 mL DMSO at rt was added l-bromopyrrolidine-2,5-dione (1.15 g, 6.44 mmol). The reaction mixture was stirred for about 30 min and then quenched with 10 mL of water. Extracted with 20 mL of EtOAc, dried with MgS04 and concentrated in vacuo to afford the title compound (0.6 g, 51%) LC/MS (Table 1, Method f) Rt = 0.1 min; MS m/z: 193, 195 (M+H)+.
As the paragraph descriping shows that 61363-56-2 is playing an increasingly important role.
Reference£º
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
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