85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (rac)-ethyl 4,5-dimethyl-17-[3-(naphthalen-1-yloxy)propyl]-7,8,9,14-tetrahydro-5H- indolo[1 ,7-bc]pyrazolo[4,3-e][2,8]benzodiazacycloundecine-16-carboxylate (see intermediate 31, 150 mg, 251 mihoI), (1H-benzotriazol-1-yloxy)(tripyrrolidin-1-yl)phosphonium hexafluorophosphate (143 mg, 276 pmol), tetrahydro-2H-pyran-4-ylacetic acid (CAS 85064-61- 5, 39.7 mg, 276 pmol) and N,N-diisopropylethylamine (87 mI, 500 mmol) in DMF (3 ml_) was stirred at ambient temperature for 90 minutes. After removal of all volatiles, the residue was subjected to flash chromatography (Biotage SNAP cartridge silica, dichloromethane/ethanol gradient, 0% -> 10% ethanol) to give the title compound (177 mg).LC-MS (Method 2): Rt= 1.70 min; MS (ESIpos) : m/z = 726 [M+H]+1H-NMR (400 MHz, DMSO-d6) d [ppm]: 0.884 (1.91), 0.902 (3.95), 0.920 (1.91), 0.992 (0.60), 1.009 (0.64), 1.035 (7.16), 1.052 (16.00), 1.070 (8.00), 1.165(1.17), 1.185(1.27), 1.196 (1.17), 1.220 (3.92), 1.237 (7.67), 1.255 (3.51), 1.564 (0.90), 1.598 (0.84), 1.626 (0.94), 1.658 (0.80), 1.726 (9.47), 1.791 (0.44), 1.985 (0.67), 2.065 (5.29), 2.084 (1.07), 2.092 (0.50), 2.308 (1.64), 2.322 (2.91), 2.327 (3.21), 2.331 (2.48), 2.336 (1.74), 2.388 (1.10), 2.402 (1.07), 2.420 (1.54), 2.438 (1.67), 2.456 (1.37), 2.518 (7.67), 2.523 (4.99), 2.665 (1.44), 2.669 (1.97), 2.673 (1.44), 3.245 (0.97), 3.257 (1.07), 3.274 (1.81), 3.281 (1.67), 3.370 (1.51), 3.388 (2.11), 3.405 (2.18), 3.417 (1.57), 3.422 (3.62), 3.435 (3.62), 3.440 (3.45), 3.452 (3.48), 3.457 (1.17), 3.469 (1.10), 3.499 (1.07), 3.535 (1.24), 3.547 (1.04), 3.589 (0.97), 3.716 (1.24), 3.771 (10.64), 3.802 (1.64), 3.816 (1.37), 4.202 (0.57), 4.217 (0.97), 4.226 (1.27), 4.242 (2.74), 4.260 (3.51), 4.274 (2.61), 4.277 (2.54), 4.344 (2.38), 4.356 (4.52), 4.369 (2.18), 4.582 (0.87), 4.623 (0.80), 5.052 (0.54), 5.087 (0.50), 5.345 (0.94), 5.387 (1.44), 5.522 (1.51), 5.564 (0.94), 5.759 (4.02), 6.446 (1.17), 6.466 (1.24), 6.804 (0.40), 6.821 (0.54), 6.837 (1.71), 6.855 (1.87), 6.916 (2.01), 6.934 (2.64), 6.949 (1.14), 6.969 (0.67), 7.028 (1.77), 7.048 (2.71), 7.066 (1.84), 7.075 (1.71), 7.090 (3.25), 7.108 (0.67), 7.168 (0.77), 7.381 (1.94), 7.402 (3.65), 7.421 (2.88), 7.461 (3.92), 7.482 (2.18), 7.504 (0.60), 7.517 (1.77), 7.523 (2.78), 7.531 (3.15), 7.541 (2.91), 7.546 (1.87), 7.559 (0.74), 7.727 (0.50), 7.746 (2.1 1 ), 7.765 (1.64), 7.868 (2.14), 7.878 (0.90), 7.885 (1 .74), 7.892 (1 .71 ), 8.267 (1 .41 ), 8.273 (1.14), 8.290 (1.10).
The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; THEDE, Kai; MENGEL, Anne; CHRIST, Clara; KUHNKE, Joachim; JOHANNES, Sarah, Anna, Liesa; BUCHGRABER, Philipp; KLAR, Ulrich; SACK, Ulrike; KAULFUSS, Stefan; FERNANDEZ-MONTALVAN, Amaury, Ernesto; WERBECK, Nicolas; MOeNNING, Ursula; FERRARA, Steven, James; SERRANO-WU, Michael, H.; LEMKE, Chris; MCKINNEY, David; FITZGERALD, Mark; NASVESCHUK, Christopher; LAZARSKI, Kiel; FURST, Laura; WEI, Guo; MACCARREN, Patrick, Ryan; HARVEY, Rebecca, Ann; WILSON, Craig; (406 pag.)WO2019/96907; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics