Simple exploration of 110238-91-0

110238-91-0 Methyl tetrahydro-2H-pyran-4-carboxylate 2773520, aTetrahydropyrans compound, is more and more widely used in various.

110238-91-0, Methyl tetrahydro-2H-pyran-4-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ammonium hydroxide (1 L) was added to a solution of methyl tetrahydro-2H- pyran-4-carboxylate (20 ML, 150 mmol) in methanol (500 mL), and the reaction was stirred overnight at ambient temperature. Additional ammonium hydroxide (500 ML) was added, and the reaction was stirred for four additional days. The methanol was removed under reduced pressure. Solid sodium chloride was added to the aqueous layer, which was extracted with chloroform (3 x 150 mL). The combined extracts were dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide 11.4 g of tetrahydro- 2H-PYRAN-4-CARBOXAMIDE as a white solid.

110238-91-0 Methyl tetrahydro-2H-pyran-4-carboxylate 2773520, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/20999; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 38041-19-9

38041-19-9 Tetrahydro-2H-pyran-4-amine 419223, aTetrahydropyrans compound, is more and more widely used in various.

38041-19-9, Tetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a flask having an inner volume of 20 L, made of glass and equipped with a stirring device, a thermometer, a dropping funnel and a reflux condenser were charged 5873 g (115 mol) of 98percent aqueous hydrazine solution and 2072 ml of ethanol, and the mixture was heated to 75¡ãC with stirring. Then, a solution in which 2136 g (11.5 mol) of tetrahydropyranyl-4-methanesulfonate with a purity of 70percent had been dissolved in 2072 ml of ethanol was gradually added dropwise to the mixture, and the mixture was reacted at the same temperature for 4 hours with stirring. After completion of the reaction, the mixture was cooled to room temperature to obtain a reaction mixture comprising 4-hydrazinotetrahydropyran as a main product. Then, to a flask having an inner volume of 20 L, made of glass and equipped with a stirring device, a thermometer, a dropping funnel and a reflux condenser were charged 414.4 g (4.6 mol calculated as nickel atom) of 65percent by weight developed Raney nickel and 2072 ml of water, and the mixture was heated up to 60¡ãC with stirring. Then, the reaction mixture was gradually added dropwise, and the resulting mixture was reacted at 80¡ãC for 2 hours with stirring. After completion of the reaction, the reaction mixture was cooled up to 40¡ãC, Raney nickel was filtered off, and the filtrate was concentrated under reduced pressure to obtain 818.0 g of the reaction solution containing 4-aminotetrahydropyran as a main product. To a flask having an inner volume of 20 L, made of glass and equipped with a stirring device, a thermometer, a dropping funnel, a reflux condenser and a distillation device under reduced pressure were charged the above reaction solution, 2072 ml (10.9 mol) of tetraethylenepentamine and 4100 ml of n-butyl alcohol, and the mixture was stirred at 80¡ãC for 2 hours under reduced pressure. Then, 4-aminotetrahydropyran and n-butyl alcohol were removed by azeotropic distillation under reduced pressure. Thereafter, 4100 ml of n-butyl alcohol was added again, 4-aminotetrahydropyran and n-butyl alcohol were removed by azeotropic distillation under reduced pressure. This operation was repeated to three times to obtain 15000 ml of a distilled solution in total. To the distilled solution was added 575 ml (6.90 mol) of conc. hydrochloric acid, and then, the mixture was concentrated under reduced pressure. To the concentrate was again added 8200 ml of n-butyl alcohol, and water and n-butyl alcohol were removed by azeotropic distillation under reduced pressure. Then, 7460 ml of n-butyl alcohol and 3730 ml of ethanol were added to the residue, and the resulting mixture was once heated up to 115¡ãC and stirred, then, it was gradually cooled to -5¡ãC and stirred for 30 minutes. After the filtration, the filtrate was washed with cooled toluene and dried to obtain 788.9 g (Isolation yield based on tetrahydropyranyl-4-methanesulfonate: 50percent) of 4-aminotetrahydropyran hydrochloride with a purity of 99percent (internal standard method by gas chromatography) as white needle-like crystals. Physical properties of the 4-aminotetrahydropyran hydrochloride were the same as those in Example 2(2).

38041-19-9 Tetrahydro-2H-pyran-4-amine 419223, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Ube Industries, Ltd.; EP1661894; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 130290-79-8

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130290-79-8,(Tetrahydro-2H-pyran-4-yl)methanamine,as a common compound, the synthetic route is as follows.

EXAMPLE IF3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide ; 4-Fluoro-3-nitrobenzenesulfonamide (2.18 g), (tetrahydropyran-4-yl)methylamine (1.14 g), and triethylamine (1 g) were stirred in tetrahydrofuran (30 mL) for 24 hours. The solution was diluted with ethyl acetate, washed with NaH2PO4 solution and brine, and dried (Na2SO4), filtered and concentrated. The product was triturated from ethyl acetate.

130290-79-8 (Tetrahydro-2H-pyran-4-yl)methanamine 2773210, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; BRUNCKO, Milan; DING, Hong; DOHERTY, George, A.; ELMORE, Steven, W.; HASVOLD, Lisa; HEXAMER, Laura; KUNZER, Aaron, R.; MANTEI, Robert, A.; MCCLELLAN, William, J.; PARK, Chang, H.; PARK, Cheol-min; PETROS, Andrew, M.; SONG, Xiaohong; SOUERS, Andrew, J.; SULLIVAN, Gerard, M.; TAO, Zhi-fu; WANG, Gary, T.; WANG, Le; WANG, Xilu; WENDT, Michael, D.; WO2010/65865; (2010); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Downstream synthetic route of 33024-60-1

As the paragraph descriping shows that 33024-60-1 is playing an increasingly important role.

33024-60-1, Tetrahydro-2H-pyran-4-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step D; To a mixture of the compound described in Step C, Example 2 (240 mg, 0.455 mmol), 4- amino tetrahydrofuran HC1 salt (63 mg, 0.455 mmol), molecular sieve (9i, 200 mg), DIEA (7011L, 0.455 mmol) in DCM (15 mL), was added sodium triacetoxyborohydride (482 mg, 2.275 mmol) and the resulting mixture was stirred overnight at room temperature. The reaction was diluted with DCM, filtered through celite, and evaporated i7l vacuo. The residue was purified by preparative TLC (1000 micron, eluant: 6percent MeOH : 94percent DCM) to afford two separate single isomers (isomer 1, less polar, 75 mg, 28percent ; isomer 2, more polar, 58 mg, 22percent).

As the paragraph descriping shows that 33024-60-1 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2005/80371; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Brief introduction of 185815-59-2

As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.

185815-59-2, 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13: Preparation of (3R)-5-methyl-3-(2-oxo-2{ [Yl RVl -phenylethyl] amino} ethyl) hexanoic acid compound (24); [0087] A three-necked flask equipped with an addition funnel, thermometer pocket, drying tube and a mechanical stirrer, was charged with methanol (100 ml), (R)-(+)- phenylethylamine (35.58 g, 0.147mole) and 4-dimethylaminopyridine (0.18 g, 0.00147 mole). The mixture was cooled to a temperature of 0-5 C, followed by addition of a solution of 3-isobutyl glutaric anhydride (25 g, 0.147 mole) in methanol (25 ml), over a period of 15- 20 minutes, and stirring for additional 1.5-2 hours, at a temperature of 0-5C. The solvent was stripped off and the residue was extracted with 2.5-3 percent aqueous solution of NaHCO3 solution (500 ml), and diluted with water (1000 ml) followed by washing the aqueous phase with toluene (1 x 100 ml and 1 x 50 ml). The pH of the aqueous phase was adjusted to 2-2.5 by adding a 1-12N solution of hydrochloric acid. The aqueous phase was further extracted with ethyl acetate (1 x 150 ml and 1 x 50 ml), followed by drying the combined ethyl acetates extracts over anhydrous sodium sulfate, and stripping off the solvents, to obtain a residue. The residue was crystallized from ethyl acetate and toluene mixture to get 22.2 g (51.76 percent yield) of a white solid of (3R)-5-methyl-3-(2-oxo-2- EPO {[(lR)-l-phenylethyl]amino}ethyl)hexanoic acid with an optical purity of 99.1 percent, as measured by chiral HPLC.

As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2007/35789; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Simple exploration of 110238-91-0

The synthetic route of 110238-91-0 has been constantly updated, and we look forward to future research findings.

110238-91-0, Methyl tetrahydro-2H-pyran-4-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 3: (Tetrahydropyran-4-yl)methanoI; To a suspension of LiAlFL, (56g, 1.47mol) in diethyl ether (2L) under argon was added methyl tetrahydro-2H-pyran-4-carboxylate (270g, 1.88mol) in diethyl ether (ca. 200mL) under reflux over a period of 1.75h. After addition was complete reflux was continued for a further lh. TLC (diethyl ether) indicated a small amount of ester remained, so further LiAlFL, (lOg, 0.26mol) was added and reflux continued for lh. Water (66mL) was added, then 15% NaOH solution (66mL), followed by further water (198mL). The solid was filtered and dried to give the crude product, which was redissolved in DCM (800 ml), dried (MgS04),filtered and the solvent removed to afford the title compound (207 g, 94% yield). NMR was consistent with the above structure.

The synthetic route of 110238-91-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROSIDION LIMITED; WO2006/16174; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 29943-42-8

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

NaH (mass fraction 60%, 5g, 125mmol) at room temperature Add slowly to tetrahydrofuran (200 mL), After the addition was complete, tetrahydro-4H-pyran-4-one (5.0 g, 50 mmol) was added. And dimethyl carbonate (10 mL, 125 mmol). The reaction system was heated to 60 C, and the reaction was stirred for 24 hours. After the reaction was detected to be complete by LC-MS, suction filtration was performed. The filtrate was adjusted to neutral pH with acid, extracted with ether, and separated. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated, and purified by silica gel column chromatography to obtain 4 -Oxotetrahydro-2H-pyran-3-carboxylic acid Methyl ester (3.6 g, 22.8%).

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Fujian Tuoxi New Materials Technology Co., Ltd.; Weng Songqing; (8 pag.)CN110407843; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 125995-03-1

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.

50.0 g of atorvastatin lactone was suspended in a mixture of 150 a of t-butyl methyl ether and 100 ml of acetone, and 3.7 g of strontium hydroxide dissolved in 200 ml of water was slowly added thereto over 30 minutes, and stirred at room temperature for 3 hours. After removing the organic layer, 150 ml of t-butyl methyl ether was added to the aqueous layer, followed by stirring at room temperature for 10 minutes. The organic layer was again removed, and 200 ml of acetone was added to the aqueous layer. The mixture was warmed to 50 C., to which 10.2 g of strontium acetate dissolved in 250 ml of water was slowly added over 2 hours, stirred at 50 C. for 8 hours, and the resulting solution was cooled to room temperature. The precipitate formed was filtered, washed with a mixture of 60 ml of acetone and 90 ml of water and dried in air, to obtain 50.7 g of the title compound (yield: 85%) as a white crystalline powder.Moisture content (Karl-Fisher titrator): about 6.9%Based on the result of such moisture content analysis, the crystalline powder obtained above was confirmed to be the pentahydrate form of formula (Ia), and its XRPD result showed that it is a crystal having distinctively characteristic main peaks (those having I/Io of at least 10%), as shown in Table 1. Accordingly, the crystalline powder obtained above is designated Form I.

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; HANMI PHARM. CO., LTD.; US2010/120888; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

New learning discoveries about 1194-16-7

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.

To a stirred solution of compound 1 (3.2 g, 25 mmol) in methanol (8 mL) was added malononitrile (1.65 g, 25 mmol), followed by carbon disulfide (3 mL, 50 mmol). Triethylamine (1.5 mL, 10.8 mmol) was added dropwise. The reaction was exothermic. After stirring for 24 hr, the formed solid was filtered, rinsed with diethyl ether and dried in vacuum to provide compound 2 (2.7 g, 43%) as an orange-colored solid. NMR (DMSO-ife): 8.91 (br s, 2H), 4.46 (s, 2H), 2.57 (s, 2H), 1.19 (s, 6H). (ESI) MS: 253.0 [M+l]

1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; MICROBIOTIX, INC.; OPPERMAN, Timothy, J.; NGUYEN, Son, T.; KWASNY, Steven, M.; DING, Xiaoyuan; WO2014/179784; (2014); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

Some tips on 110238-91-0

The synthetic route of 110238-91-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110238-91-0,Methyl tetrahydro-2H-pyran-4-carboxylate,as a common compound, the synthetic route is as follows.

Methyl tetrahydro-2H-pyran-4-carboxylate (5 g, 34.68 mmol, 1.0 equiv) was dissolved in THE (60 mL) and methanol (10 mL). Sodium borohydride (2.62 g, 69.36 mmol, 2.0 equiv) was added in portions and the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was quenched with saturated aqueous ammonium chloride solution and extracted with EtOAc. The organic layer was washed with brine, dried over sodium sulfate and concentrated to afford the desired product 3.1.22a (3.2 g, 80 % yield). 1H NMR (400 MHz, DMSO) 6 3.96 – 3.75 (m, 2H), 3.66 – 3.58 (m, 2H), 3.36 (dd, J = 6.9, 4.7 Hz, 2H), 3.33-3.17 (m, 2H), 1.81-1.70 (m, 2H), 1.63-1.48 (m, 2H).

The synthetic route of 110238-91-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; FU, Jiping; LEE, Patrick; MADERA, Ann Marie; SWEENEY, Zachary Kevin; WO2015/66413; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics