With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.
To a stirred solution of compound 1 (3.2 g, 25 mmol) in methanol (8 mL) was added malononitrile (1.65 g, 25 mmol), followed by carbon disulfide (3 mL, 50 mmol). Triethylamine (1.5 mL, 10.8 mmol) was added dropwise. The reaction was exothermic. After stirring for 24 hr, the formed solid was filtered, rinsed with diethyl ether and dried in vacuum to provide compound 2 (2.7 g, 43%) as an orange-colored solid. NMR (DMSO-ife): 8.91 (br s, 2H), 4.46 (s, 2H), 2.57 (s, 2H), 1.19 (s, 6H). (ESI) MS: 253.0 [M+l]
1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; MICROBIOTIX, INC.; OPPERMAN, Timothy, J.; NGUYEN, Son, T.; KWASNY, Steven, M.; DING, Xiaoyuan; WO2014/179784; (2014); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics