Some tips on 110238-91-0

The synthetic route of 110238-91-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110238-91-0,Methyl tetrahydro-2H-pyran-4-carboxylate,as a common compound, the synthetic route is as follows.

Methyl tetrahydro-2H-pyran-4-carboxylate (5 g, 34.68 mmol, 1.0 equiv) was dissolved in THE (60 mL) and methanol (10 mL). Sodium borohydride (2.62 g, 69.36 mmol, 2.0 equiv) was added in portions and the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was quenched with saturated aqueous ammonium chloride solution and extracted with EtOAc. The organic layer was washed with brine, dried over sodium sulfate and concentrated to afford the desired product 3.1.22a (3.2 g, 80 % yield). 1H NMR (400 MHz, DMSO) 6 3.96 – 3.75 (m, 2H), 3.66 – 3.58 (m, 2H), 3.36 (dd, J = 6.9, 4.7 Hz, 2H), 3.33-3.17 (m, 2H), 1.81-1.70 (m, 2H), 1.63-1.48 (m, 2H).

The synthetic route of 110238-91-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; FU, Jiping; LEE, Patrick; MADERA, Ann Marie; SWEENEY, Zachary Kevin; WO2015/66413; (2015); A1;,
Tetrahydropyran – Wikipedia
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