With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.
A solution of 2-[(2-amino-5-methoxyphenyl)disulfanyl]-4-methoxy- aniline (llb-4) (0.337 g, 1 .09 mmol) and oxane-3,5-dione (III-5) (0.250 g, 2.19 mmol) in ethanol (7 ml) and triethylamine (0.5 ml) was refluxed for 16 hours. After completion of the reaction the mixture was concentrated to dry- ness under reduced pressure. The yield after flash chromatography (100-200 mesh size silica gel, 25% ethyl acetate in hexane) was 10 mg.
The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MEDEIA THERAPEUTICS LTD; RATILAINEN, Jari; GOLDSTEINS, Gundars; WO2014/191632; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics