With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.
4-Cyano-tetrahydropuran(500 mL) in methanolic ammonia (200 mL) was hydrogenated in the presence of Raney nickel (10 g) under a pressure of 4 to 5 kg/cm2 hydrogen gas for 12hours at 45 After cooling, the reaction solution was filtered through a Celite bed. The reaction mixture was distilled at 55 C to provide the desired product (60 g, Yield: 0.60 w/w).
The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
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