Analyzing the synthesis route of 4295-99-2

The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.

Into a 1 L glass flask equipped with a stirrer, a thermometer, a gas inlet tube and a reflux condenser, 5.01 g (45.1 mmol) of 4-cyanotetrahydropyran,1.50 g (46.8 mmol) of methanol and 33.5 g of methylene chloride were added,While bubbling hydrogen chloride gas, reaction was carried out at 0 to 5 C. while stirring.After completion of the reaction, nitrogen was bubbled through the reaction liquid to obtain a slurry.Then, into a glass flask having an internal volume of 300 ml and equipped with a separate stirring device, a thermometer and a reflux condenser,6.90 g (68.2 mmol) of triethylamine, 4.10 g of a 19.1 mass% ammonia ¡¤ methanol solution and 6.20 g of methanol were mixed,The slurry obtained above was added and reacted at 0 to 5 C. for 2 hours.After completion of the reaction, the resultant reaction solution was analyzed, and the presence of tetrahydropyran-4-carboxamidine was confirmed.

The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UBE INDUSTRIES LIMITED; NAKATANI, RYO; IWATA, TOMOCHIKA; FUKUHARA, YASUAKI; MOTOYAMA, TAKAHIRO; (34 pag.)JP6183053; (2017); B2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics