With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.
Into a 1 L glass flask equipped with a stirrer, a thermometer, a gas inlet tube and a reflux condenser, 5.01 g (45.1 mmol) of 4-cyanotetrahydropyran,1.50 g (46.8 mmol) of methanol and 33.5 g of methylene chloride were added,While bubbling hydrogen chloride gas, reaction was carried out at 0 to 5 C. while stirring.After completion of the reaction, nitrogen was bubbled through the reaction liquid to obtain a slurry.Then, into a glass flask having an internal volume of 300 ml and equipped with a separate stirring device, a thermometer and a reflux condenser,6.90 g (68.2 mmol) of triethylamine, 4.10 g of a 19.1 mass% ammonia ¡¤ methanol solution and 6.20 g of methanol were mixed,The slurry obtained above was added and reacted at 0 to 5 C. for 2 hours.After completion of the reaction, the resultant reaction solution was analyzed, and the presence of tetrahydropyran-4-carboxamidine was confirmed.
The synthetic route of 4295-99-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UBE INDUSTRIES LIMITED; NAKATANI, RYO; IWATA, TOMOCHIKA; FUKUHARA, YASUAKI; MOTOYAMA, TAKAHIRO; (34 pag.)JP6183053; (2017); B2;,
Tetrahydropyran – Wikipedia
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