With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1768-64-5,4-Chlorotetrahydropyran,as a common compound, the synthetic route is as follows.
440 mg (12.7 mmol, 1.1 eq.) of NaH was added into the solution of 2 g (11.5 mmol, 1 eq.) 2-chloro-5-nitrophenol in DMF, and stirred for 1 hr at rt. And then, 1.5 g (12.7 mmol, 1.1 eq) of 4-chloro-2H-tetrahydropyran was added and stirred overnight. After the reaction was complete, water was added and filtered to remove solvent. The product was purified by column chromatography to obtain 1.7 g of 1, with a yield of 70%.
The synthetic route of 1768-64-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhejiang Beta Pharma Incorporation; Fujian Haixi Pharmaceuticals, Inc.; Kang, Xinshan; Long, Wei; Ma, Cunbo; Wang, Yanping; Shen, Xiaoyan; Hu, Yunyan; Tan, Fenlai; Wang, Yinxiang; US2013/225587; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics