65412-03-5, 4-(2-Aminoethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65412-03-5
5.1.79 EXAMPLE 79: SYNTHESIS OF 6-(4-HYDROXYPHENYL)- 1 -(2-(TETRAH YDRO-2H-P YRAN-4- YL)ETH YL)- 1 H- IMIDAZO[4,5-B]PYRAZIN-2(3H)-ONE[00466) A. 6-(4-Hydroxyphenyl)-l-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-lH- imidazo[4,5-b]pyrazin-2(3H)-one. 4-(6-Bromo-5-(N,N-bis-boc-amino)pyrazin-2- yl)phenol {see Example 46.F) (100 mg, 0.2 mmol), 2-(tetrahydro-2H-pyran-4-yl)ethanamine (0.28 g, 2 mmol), and N-methylpyrrolidinone (2 mL) were heated in a Biotage Emrys Optimizer microwave reactor at 150 C for 10 min. The reaction was extracted with water and ethyl acetate. The organic layer was concentrated and then purified by reverse-phase semi-preparatory HPLC (5-70% acetonitrile + 0.1 % TFA in H2O + 0.1 % TFA, over 30 min). Product fractions were concentrated and then triturated with ether to give a white solid (45 mg, 62 % yield). 1H NMR (400 MHz, DMSO-^6) delta 11.92 (s, IH), 9.70 (s, IH), 8.37 (s, IH), 7.84 (d, J=8.6, 2H), 6.86 (d, J=8.6, 2H), 3.91 (t, J=7.0, 2H), 3.79-3.85 (m, 2H), 3.21 (td, J=I 1.7, 2.0, 2H), 1.67 – 1.75 (m, 4H), 1.44-1.53 (m, IH), 1.15-1.25 (m, 2H); MS (ESI) m/z 341.0 [M+ 1]+; mp 276-277 C.
The synthetic route of 65412-03-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2008/51493; (2008); A2;,
Tetrahydropyran – Wikipedia
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