19752-84-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.
Compound 2 (300 g, 2.9 mol) was dissolved in 3000 g of dichloromethane and sodium acetate (287 g, 3.5 mol) was added.TEMPO 6g, add sodium dichloroisocyanurate (374g, 1.7mol) in batch at 25C, maintain the reaction at 25C for 2h, filter,The organic phase was dried with 200g of anhydrous sodium sulfate, filtered and concentrated in a water pump and distilled to collect the oil temperature of 120C and the top temperature of 90C.250 g of a colorless oily liquid having a purity of 99% and a yield of 83%.
The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Haimen Huaxiang Pharmaceutical Technology Co., Ltd.; Yong Dawei; Cao Zhong; Yang Shaoqiang; Lu Yi; Zhou Guang; Xu Benquan; (4 pag.)CN107382928; (2017); A;,
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