With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.,29943-42-8
At 25 C under sodium hydride (mass fraction of 60%, 10.0 g, 250 mmol) is slowly added in tetrahydrofuran (300 ml) in, after finishing feeding into the tetrahydro-4H-pyran-4-one(10.0 g, 100 mmol) and dimethyl carbonate (21 ml, 250 mmol). Heating up to 45 C stirring for 16 hours. LC – MS detection reaction is complete, filtering, the filtrate 1 mol/L hydrochloric acid to adjust the pH=7 after ethyl ether (500 ml) extraction, liquid, organic phase dried with anhydrous sodium sulfate, filtered, the filtrate is concentrated, crude product by silica gel column chromatography (petroleum ether: ethyl acetate=50:1) purify the title compound (3.0 g, yield 19.0%).
The synthetic route of 29943-42-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu Yongqian; (20 pag.)CN107286169; (2017); A;,
Tetrahydropyran – Wikipedia
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