With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.
General procedure: Ethyl 4-oxocyclohexanecarboxylate (2.79 ml, 17.6 mmol), malononitrile (1.16 g, 17.6 mmol), sulfur (0.564 g, 19.4 mmol) and diethylamine (1.82 ml, 17.6 mmol) were stirred at 70 oC for 16 h in ethanol (10 ml). After cooling, the solvent was removed and the residue was dissolved in ethyl acetate (10 ml). The organic layer was then washed with water (3 x 10 ml), dried (magnesium sulfate), and concentrated in vacuo to give the thiophene as a pale orange solid (4.46 g)., 1194-16-7
As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.
Reference£º
Article; Sleebs, Brad E.; Nikolakopoulos, George; Street, Ian P.; Falk, Hendrik; Baell, Jonathan B.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5992 – 5994;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics