85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
85064-61-5, General procedure: To(1S,1?S)-1,1?-(5,5?-([1,1?-biphenyl]-4,4?-diyl)bis(1H-imidazole-5,2-diyl))bis(2,2-dimethylpropan-1-amine)tetrahydrochloride(75 mg, 0.124 mmol) was added3-hydroxy-2,2,3-trimethylbutanoic acid(38.2 mg, 0.261 mmol) inDMF(3 mL) followed byDIPEA(0.174 mL, 0.996 mmol) at 0¡ã C. ThenHATU(97 mg, 0.255 mmol) was added and stirred from 0¡ã C. to RT for 6 h. The crude was dissolved inEtOAc(50 mL), washed with saturated NH4Cl (25 mL), 10percent NaHCO3(25 mL), brine (25 mL), dried over Na2SO4and concentrated under reduced pressure. The crude material was purified by reverse phase HPLC (ACN/water/TFA) to getTFA saltof Example B-69 (30 mg) as awhitesolid. HPLC (Condition B-1 and B-2): >97percent homogeneity index. LC/MS (Condition B-12): Rt=2.13 min.1H NMR (MeOD, delta=3.34 ppm, 400 MHz): delta 7.92-7.85 (m, 10H), 4.94 (s, 2H), 1.28 (s, 18H), 1.16 (s, 12H), 1.15 (s, 12H). LC/MS:Anal. Calcd. for [M+H]+C42H61N6O4: 713.47; found 713.3. Example B-90-147 were prepared in a similar fashion starting from (1S,1?S)-1,1?-(5,5?-([1,1?-biphenyl]-4,4?-diyl)bis(1H-imidazole-5,2-diyl))bis(2,2-dimethylpropan-1-amine)tetrahydrochloride and appropriate acids according to the procedure described for Example B-69.
85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; Hewawasam, Piyasena; Lopez, Omar D.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Kadow, John F.; Meanwell, Nicholas A.; Gupta, Samayamuthula Venkata Satya Arun Kumar; Kumar, Indasi J. Gopi; Ponugupati, Suresh Kumar; Belema, Makonen; US2015/23913; (2015); A1;,
Tetrahydropyran – Wikipedia
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