With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
70 g of 3-isobutylglutaric acid dry product and 70 g of acetic anhydride at 120 temperature reaction 2h,To give 3-isobutylglutaric anhydride.The solution of 3-isobutylglutaric anhydride (75 g) was then slowly added dropwise to 180 g of aqueous ammonia,The control temperature is 10 C.3-isobutyl glutaric anhydride added, continue to react 2h.Finally, the pH of the solution was adjusted to 2 to 3 with hydrochloric acid and filtered to obtain a white powder solid,That is, the final product 3-isobutyl glutaric acid monoamide, liquid content of 99.8%The yield was 95%, the overall yield was 77.5%Figure 4 is a liquid phase detection of 3-isobutylglutaric acid monoamide.
185815-59-2, 185815-59-2 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione 11480690, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; Suzhou Yingnuoxin Pharmaceutical Technology Co., Ltd.; Chen, Jiaqi; Xia, Chenyi; Han, Xi; Xu, Liang; Tang, Huozhen; (12 pag.)CN106278931; (2017); A;,
Tetrahydropyran – Wikipedia
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