Day: September 10, 2020

14774-36-8, (Tetrahydropyran-3-yl)methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

169a) 3-((3-Bromophenoxy)methyl)tetrahydro-2H-pyran A solution of 3-bromophenol (500 mg, 2.89 mmol), triphenylphosphine (758 mg, 2.89 mmol) and (tetrahydro-2H-pyran-3-yl)methanol (420 mg, 3.62 mmol) in tetrahydrofuran (THF) (10 mL) was added DIAD (0.674 mL, 3.47 mmol) in tetrahydrofuran (THF) (10 mL) slowly under nitrogen at 0C. The reaction mixture was stirred at 25 C for 16 h. The solvent was evaporated and was purified by reverse-phase HPLC to obtain the title compound 3-((3-bromophenoxy)methyl)tetrahydro-2H-pyran (260 mg, 0.91 1 mmol, 31 .5 % yield). LC-MS m/z 271 .0(M+H)+, 2.10 min (ret. time)., 14774-36-8

14774-36-8 (Tetrahydropyran-3-yl)methanol 85769, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; CALLAHAN, James Francis; KERNS, Jeffrey K.; LI, Peng; LI, Tindy; MCCLELAND, Brent W.; NIE, Hong; PERO, Joseph E.; DAVIES, Thomas Glanmor; GRAZIA CARR, Maria; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; NORTON, David; VERDONK, Marinus Leendert; WOOLFORD, Alison Jo-Anne; WILLEMS, Hendrika Maria Gerarda; (664 pag.)WO2017/60854; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

25850-22-0, 2,2-Dimethyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 4-((2-chloro-5-nitropyrimidin-4-yl)amino)cyclohexane-1-carboxamide (0.5 g, 2.2 mmol) in DMF (10 mL) was added 2,2-dimethyltetrahydro-2H-pyran-4-amine (0.24 g, 1.8 mmol) and sodium carbonate (0.53 g, 5.0 mmol) at ambient temperature. The reaction mixture was stirred at ambient temperature for 16 h. Completion of the reaction was confirmed by UPLC. The product was isolated and triturated with petroleum ether to afford (1S,4S)-4-((2-((2,2-dimethyltetrahydro-2H-pyran-4-yl)amino)-5-nitropyrimidin-4-yl)amino)cyclohexane-1-carboxamide (0.4 g, 61%) as an yellow solid. MS (ESI) m/z 393.2 [M+1]+., 25850-22-0

As the paragraph descriping shows that 25850-22-0 is playing an increasingly important role.

Reference£º
Patent; Celgene Corporation; CANAN, Stacie S.; HAWRYLUK, Natalie Anne; WITTY, Michael John; (74 pag.)US2017/348315; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

A solution of 2- (4-methoxymethylsulfanylphenyl)-3- (tetrahydropyran-4-yl)-N thiazol-2-ylpropionamide (EXAMPLE 77,1. 29g, 3. 28MMOL) in THF (50ML) was added to a stirred solution OF AGN03 (0.59g, 3. 28MMOL) in ETOH (85mL) at 40 C. The mixture was protected from light and stirred at 40 C for 21h. The solvents were evaporated off under reduced pressure, then the remaining solid was triturated with i-PrOH (60mL), THF (60mL), and ET20 (60mL). After air-drying, the solid was stirred vigorously with CH2C12 (200mL) and 6M HCl (82mL) for 4h under Ar. The layers were separated, then the aqueous phase was extracted with CH2Cl2 (2 x 100ML). The combined organic extracts were filtered through Celite, washed with brine (LOOML) and dried (MGS04). Filtration and solvent evaporation furnished 2- (4- MERCAPTOPHENYL)-3- (TETRAHYDROPYRAN-4-YL)-N-THIAZOL-2-YLPROPIONAMIDE : m/z (ES+) = 349.2 [M + H] +. NEt3 (0.14mL, 1006mumol) and a solution of 4- iodomethyltetrahydropyran (151 mg, 668MOL) in anhydrous DMF (3mL) were added to a stirred solution of this benzenethiol (197mg, 565, UMOL) in anhydrous DMF (7mL) at 0 C. The mixture was warmed to 20 C, before being stirred for 16h. The solvents were evaporated off under reduced pressure, then the residue was partitioned between CH2C12 (25ML) and 2% aqueous citric acid (lOmL). The aqueous layer was extracted with CH2C12 (10mL), then the combined organic layers were washed with H20 (LOML), saturated aqueous NA2C03 (LOML), H20 (LOML), and brine (LOML). After drying (MGS04), filtration and solvent evaporation gave a residue that was subjected to flash chromatography (1H ETOAC, 3: 1 to 0: 1) to furnish the title compound: RTA= 3. 61MIN ; MLZ (ES+) = 447.3 [M+ H]+.

101691-94-5, 101691-94-5 4-(Iodomethyl)tetrahydro-2H-pyran 2795507, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; OSI PHARMACEUTICALS, INC.; WO2004/72031; (2004); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245724-46-2,(S)-Tetrahydro-2H-pyran-3-amine hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of (R)-1-(8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidin-6-yl)ethyl benzoate synthesized by the process described in Example 3 (360 mg, 1.0 mmol), (S)-tetrahydro-2H-pyran-3-amine hydrochloride (206 mg, 1.5 mmol), and potassium carbonate (415 mg, 3.0 mmol) in 1,4-dioxane (4.0 mL) was stirred at 100C overnight. The reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to room temperature. The reaction mixture was diluted with water, and the mixture was extracted twice with ethyl acetate (10 mL). The resultant organic phase was washed with brine and dried over anhydrous magnesium sulfate. The solid was separated by filtration, and the filtrate was concentrated under reduced pressure. The resultant crude product was purified by silica gel column chromatography to yield the title compound (232 mg, 55%). 1H-NMR (CDCl3)delta: 8.97 (1H, s), 8.17-8.14 (2H, m), 7.62-7.57 (1H, m), 7.51-7.46 (2H, m), 6.87 (1H, s), 6.65 (1H, d, J=7.8 Hz), 6.10 (1H, q, J=6.7 Hz), 4.39-4.31 (1H, m), 4.08-4.03 (1H, m), 3.82-3.76 (1H, m), 3.70-3.64 (1H, m), 3.56-3.51 (1H, m), 2.65 (3H, s), 2.09-2.02 (1H, m), 1.89-1.78 (2H, m), 1.76-1.65 (4H, m) LC/MS: (M+H)+=425.2, C22H24N4O3S=424.16, 1245724-46-2

1245724-46-2 (S)-Tetrahydro-2H-pyran-3-amine hydrochloride 60145922, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Teijin Pharma Limited; MIZUNO, Tsuyoshi; SHIMADA, Tomohiro; UNOKI, Gen; EBISAWA, Masaru; TAKEUCHI, Susumu; MINAMIZONO, Kunio; SASAKI, Kosuke; YOKOSAKA, Takuya; IGARASHI, Junji; MARUYAMA, Akinobu; TAKAHASHI, Hiroshi; HORIE, Kyohei; SAKAI, Yuri; (447 pag.)EP3305785; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N-methyltetrahydro-2H-pyran-4-ammonium chloride (37 mg) in dichloromethane (2 mL) was added DIPEA (43 mul), compound 48-2 (29 mg) and molecular sieves (200 mg). The reaction mixture was stirred at room temperature for 10 minutes, followed by the addition of sodium triacetoxyborohydride (52 mg). After stirring 18 hours, the reaction mixture was diluted with CH2Cl2, washed with saturated NaHCO3 and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give a residue. The residue was purified by prep TLC on silica gel (dichloromethane/methanol / 15N NH40H aqueous solution = 90 : 9 : 1 ) to give compound 48-3. ESI-MS calc.for C37H46ClF2N5O3: 681; Found: 682 (M+H).

220641-87-2, As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2007/47496; (2007); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

185815-59-2, 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

G placed these substances in the reaction vessel was 0.58 mass urea (of substance to substance C is 1 meter). It was heated to 30 , stirring the reaction time was 1h. Using conventional separation means, separated3-isobutyl-iso-imide, named this substance D., 185815-59-2

The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Taicang Yuntong Biochemical Engineering Co., Ltd.; Zhang, Weidong; (11 pag.)CN105348123; (2016); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

72886-97-6, (S)-Tetrahydro-2H-pyran-3-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72886-97-6

A solution of 51 mg of compound 1 tetrahydropyran-3 (S) -cytanol (0.5 mmol) was dissolved in 3 ml of dichloromethane, 55 mg of Et3N (0.55 mmol)4-dimethylaminopyridine DMAP (3 mg, 0.025 mmol) under argon to a temperature of 0 C,92 mg of cinnamoyl chloride (0.55 mmol) was added to room temperature for 2 h. Then, the saturated sodium bicarbonate solution was added and the dichloromethane was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated to give the compound 1-a as a white solid (105 m g, 0.45 mmol) 90%.

72886-97-6 (S)-Tetrahydro-2H-pyran-3-ol 12256035, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Zhengzhou Taijihongnuo Pharmaceutical Co., Ltd.; Wu Yusheng; Geng Yang; Zou Dapeng; Niu Chengshan; Li Jingya; Zheng Maolin; Liang Apeng; (12 pag.)CN107253939; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.

To a solution of tetrahydro-2H-pyran-4-ol (500 mg, 4.90 mmol) in DCM (16 mL) was added TEA (0.882 mL, 6.36 mmol) followed by MsCl (0.458 mL, 5.87 mmol) at 0 C. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with DCM, washed with water, 2 N aq. HCl, saturated aq. NaHCO3, and brine successively, dried over Na2SO4, filtered and concentrated in vacuo to afford tetrahydro-2H-pyran-4-yl methanesulfonate (882 mg, 100%) as a colorless oil, which was used for the next reaction without further purification. 1H-NMR (CDCl3, Varian, 400 MHz): delta 1.84-1.92 (2H, m), 2.03-2.07 (2H, m), 3.04 (3H, s), 3.52-3.58 (2H, m), 3.92-3.97 (2H, m), 4.87-4.93 (1H, m).

2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.

Pyridinium chlorochromate (445mg,)Add to the reaction flask and dissolve with 5 mL of dichloromethane.45 (200 mg,) was slowly added dropwise to a solution of pyridinium chlorochromate in dichloromethane.The reaction was carried out for 1.5 h at room temperature, and the reaction was completely detected by TLC, and filtered with celite.Column chromatography (PE: EA = 5:1) gave a colorless, transparent liquid, 124 mg, yield 63%., 14774-37-9

As the paragraph descriping shows that 14774-37-9 is playing an increasingly important role.

Reference£º
Patent; Xihua University; Qian Shan; Li Guobo; Chen Yang; Li Chao; Zhang Man; Wang Zhouyu; Yang Lingling; Lai Peng; (16 pag.)CN108689938; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.

Example 7-1 4-Methyltetrahydro-2H-pyran-4-ol To a solution of tetrahydro-4H-pyran-4-one in diethyl ether (lOmL), was added 0. 92M methylmagnesium bromide in tetrahydrofuran (6. 5mL) dropwise with cooling on an ice bath. The reaction mixture was warmed to room temperature and stirred for 2hrs. The reaction mixture was quenched by adding saturated aqueous NHgClt and then NaCl was added. The resulting solution was extracted with chloroform, the combined organic layer was washed with saturated aqueous NaCl, and driedoverMgSO4. Afterremovalofthesolvent, thetarget compound was given as a colorless oil (595mg). 1H-NMR (300MHz, CDCl3) : No. 1.29 (3H, s), 1. 81-1. 46 (4H, m), 3.87-3. 61 (4H, m). Mass (ES+) m/z : 117.09 (M+1)., 29943-42-8

29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; WO2005/42533; (2005); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics