With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.
Example 7-1 4-Methyltetrahydro-2H-pyran-4-ol To a solution of tetrahydro-4H-pyran-4-one in diethyl ether (lOmL), was added 0. 92M methylmagnesium bromide in tetrahydrofuran (6. 5mL) dropwise with cooling on an ice bath. The reaction mixture was warmed to room temperature and stirred for 2hrs. The reaction mixture was quenched by adding saturated aqueous NHgClt and then NaCl was added. The resulting solution was extracted with chloroform, the combined organic layer was washed with saturated aqueous NaCl, and driedoverMgSO4. Afterremovalofthesolvent, thetarget compound was given as a colorless oil (595mg). 1H-NMR (300MHz, CDCl3) : No. 1.29 (3H, s), 1. 81-1. 46 (4H, m), 3.87-3. 61 (4H, m). Mass (ES+) m/z : 117.09 (M+1)., 29943-42-8
29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; WO2005/42533; (2005); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics