Day: September 11, 2020

33024-60-1, Tetrahydro-2H-pyran-4-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 1 (2. [5G)] was dissolved in acetonitrile [(15ML).] 4-Aminotetrahydropyran hydrochloride [(1.] [LG)] and N, N-diisopropylethylamine (9. [4ML)] were added and the mixture stirred under nitrogen at [85¡ãC] for 16h. A trace of starting material remained, so an additional portion of 4-aminotetrahydropyran hydrochloride [(O.] [L] lg) was added and stirring continued at [85¡ãC] for a further [16H.] The mixture was then concentrated in vacuo. The residue was partitioned between DCM and water. The layers were separated and the organic layer was washed with further water [(2X20ML)] then dried [(NA2S04)] and concentrated in vacuo. The residue was further purified by chromatography using Biotage (silica, 90g), eluting with cyclohexane: ethyl acetate to afford Example 3 (2.45g). LCMS showed MH+ [= 319] ; TRET = 2. [90MIN.]

33024-60-1, The synthetic route of 33024-60-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/24728; (2004); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.

A solution of imidazole-1-carboxylic acid cis-3= [5- (2, 2-dimethyl- propionylamino)-2H-pyrazol-3-yl]-cyclobutyl ester (200 mg) and C- (tetrahydro-pyran- 4-yl)-methylamine (83 mg) in EtOAc was stirred at 70 C overnight. After cooling, the title product was isolated by silica gel chromatography. MS (M+H) + = 379.3., 220641-87-2

The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2005/51919; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245724-46-2,(S)-Tetrahydro-2H-pyran-3-amine hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.060 g, 0.28 mmol), (3S)-tetrahydro-2H-pyran-3-amine hydrochloride (from J&W Pharmatech, 0.059 g, 0.43 mmol) and N,N-diisopropylethylamine (0.15 mL, 0.84 mmol) in isopropyl alcohol (0.95 mL) was heated at 60 C. overnight. The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 50% ethyl acetate (EtOAc) in hexanes) to give the desired product (30 mg, 38%). LCMS calculated for C12H14N3O3S (M+H)+: m/z=280.1. Found: 280.0.

1245724-46-2, The synthetic route of 1245724-46-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Incyte Corporation; Li, Yun-Long; Zhu, Wenyu; Mei, Song; Glenn, Joseph; US2014/121198; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the compound 1-1(4.75 g, 30.03 mmol) in MeOH(60 ml) was added NH4OAc(6.95 g, 90.10 mmol). After stirring for 3 h at rt, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in DCM(300 ml). The resulting mixture was washed with water(75 ml), dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the desired product 1-2(4.72 g) as a white solid.1H NMR (300 MHz, CDC13) 5 7.6 10 (brs, 1H), 6.856 (brs, 1H), 4.126 (s, 3H), 3.647 (t, J = 5.7 Hz, 2H), 3.538 (s, 3H), 2.249 (t, J = 5.7 Hz, 2H)., 127956-11-0

As the paragraph descriping shows that 127956-11-0 is playing an increasingly important role.

Reference£º
Patent; ST PHARM CO., LTD.; KIM, Kyungjin; KIM, Uk-Il; YOON, Ji Hye; (32 pag.)WO2017/99424; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103260-44-2,Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate,as a common compound, the synthetic route is as follows.

To 15 mL of tetrahydrofuran (THF) at 0 0C was added LiAlH4 (0.28 g, 7.3 mmol). This mixture was stirred for 10 min then the ethyl tetrahydropyran-4-yl-acetate (Combi- Blocks Inc., 0.50 g, 2.9 mmol) was added. The reaction was stirred for 5 min at 0 0C then was allowed to warm to ambient temperature and was stirred for 90 min. The reaction was quenched with excess NaHSO4-IOH2O and was stirred for 60 min. The mixture was filtered through Celite. The filtrate was concentrated to give the title compound which was carried on without further purification. MS (DCI/NH3) m/z 131 (M+H)+. EPO , 103260-44-2

103260-44-2 Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate 2773412, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; WO2006/69196; (2006); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

101691-94-5, 4-(Iodomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of methyl 4-bromo-7-methyl-lH-indole-6-carboxylate (Intermediate 1-2, 830 mg, 3.10 mmol) in DMF (2 mL) was added sodium hydride (186 mg, 4.64 mmol) and stirred at RT for 10 minutes. 4-(Iodomethyl)tetrahydro-2H-pyran (1050 mg, 4.64 mmol) was added and stirred at 65-70 C for 16 h. After completion of the reaction, water was added and extracted with ethyl acetate. The organic layer was purified by column chromatography (silica gel, 5-8% ethyl acetate in pet ether) to obtain the title compound. Yield: 350 mg (30 %); JH NMR (CDCI3; 300 MHz): delta 7.77 (s, 1H), 7.16 (d, J = 3 Hz, 1H), 6.54 (d, J= 3.3 Hz, 1H), 4.24 (d, J= 7.2 Hz, 2H), 3.93-3.97 (m, 2H), 3.92 (s, 3H), 2.24-2.29 (m, 2H), 2.87 (s, 3H), 1.96-1.99 (m, 1H), 1.39-1.42 (m, 4H); MS (ESI+): 367.9 [M+H]+; HPLC purity: 96.71 %., 101691-94-5

As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; GUPTE, Amol; SHARMA, Rajiv; KANDRE, Shivaji; KADAM, Kishorkumar; GUHA, Tandra; DEHADE, Amol; MORE, Tulsidas; ROYCHOWDHURY, Abhijit; WO2015/104677; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

85064-61-5, 0 ¡ãC lower, comprising the tetrahydropyran-4-acetic acid (86.5 mg, 0.6 mmol) of dichloromethane solution (5 ml) in, dropping of a catalytic amount of DMF 2 drop, and containing oxalyl (152.4 mg, 1.2 mmol) of dichloromethane solution; after the completion of the dropping, the reaction temperature to room temperature 3 hours, decompressing to evaporate the solvent; 0 ¡ãC lower, residue is dissolved in dichloromethane is used for, drop into the containing (3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-yl) cyclopentyl methanone (150 mg, 0.4 mmol) and triethylamine (121.2 mg, 1.2 mmol) in dichloromethane solution (5 ml) in, dropped, temperature to room temperature overnight the reaction; the majority of the solvent is removed under reduced pressure, by silica gel column chromatography and thick preparation plate purification to obtain white solid compound 20.0 mg, yield 10.2percent

85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Fudan University; Wang Yonghui; Tian Jinlong; Yu Mingcheng; (29 pag.)CN109134476; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.

The (tetrahydro – 2H – pyran -4 – yl) methanol (9.64 g, 83.1 mmol) and Dess – Martin oxidizing agent (35.2 g, 83.1 mmol) dissolved in dichloromethane (200 ml), the reaction solution in the stir at room temperature overnight. Filtering, the filtrate is concentrated, the crude product of the title compound obtained (9 g), as a colorless oily matter, without purification directly used for the next step reaction., 14774-37-9

14774-37-9 Tetrahydropyran-4-methanol 2773573, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Kaihui Science And Technology Development (Shanghai) Co., Ltd.; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Hu Yonghan; Cai Dongmei; Zhu Jiuxiang; Dong Ping; Li Manhua; Lin Kaiwen; Dong Jiaqiang; Wang Tielin; (93 pag.)CN108314680; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

389621-77-6, 2-(Tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DIPEA (7.99 mL, 45.8 mmol) was added to a suspension of 2-(tetrahydro-2H-pyran-4- [ 5 yl)ethanamine hydrochloride (3.63 g, 21.89 mmol) in THF (30 mL, 366 mmol) and stirred for 15 min. A solution of 4-(4-fluoro-3-nitrophenyl)-3,5-dimethylisoxazole (4.7 g, 19.90 mmol) in THF (40 mL, 488 mmol) was added to the suspension and stirred at RT for a further 2h. DMF (10 mL, 129 mmol) was added and the reaction stirred at RT for a further 2h. The reaction was heated at 50C for 20h and then at 70C for a further 10 20h. The solvent volume was reduced by evaporation in vacuo and the residue diluted with EtOAc (200 mL). The solution was washed with water (3 x 50mL) and brine (30 mL), dried (MgS04), filtered and evaporated in vacuo. The residual solid was purified by chromatography on the Companion (220 g column, 0-30% EtOAc in (2: 1 DCM/isohexane), loaded in DCM) to give 4-(3,5-dimethylisoxazol-4-yl)-2-nitro-N-(2- 15 (tetrahydro-2H-pyran-4-yl)ethyl)aniline (5.6 g, 80%) as a orange solid; m/z 346 (M+H)+ (ES+).

389621-77-6, As the paragraph descriping shows that 389621-77-6 is playing an increasingly important role.

Reference£º
Patent; CELLCENTRIC LTD; PEGG, Neil Anthony; TADDEI, David Michel Adrien; ONIONS, Stuart Thomas; TSE, Eric Sing Yuen; BROWN, Richard James; MYCOCK, David Kenneth; COUSIN, David; PATEL, Anil; (135 pag.)WO2016/170324; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.

EXAMPLE 11 Preparation of 3-Tetrahydropyranyl 2-(Methylthio-5-(2-Chloro-4-trifluoromethylphenoxy)benzoate 3-Hydroxytetrahydropyran (0.04 mole), toluene (50 ml) and triethylamine (0.04 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer and addition funnel. A solution of 2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzoyl chloride (0.04 mole) in toluene (20 ml) is slowly added at room temperature with stirring. After the addition is completed, stirring is continued for a period of about eight hours. After this time, the reaction mixture is washed with water and dried over anhydrous magnesium sulfate. The dried solution is then stripped of solvent is then stripped of solvent under reduced pressure leaving a residue. This residue is purified by silica gel chromatography using toluene and ethyl acetate/toluene mixture as the eluant to yield the desired product 3-tetrahydropyranyl 2-methylthio-5-(2-chloro-4-trifluoromethylphenoxy)benzoate., 19752-84-2

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sandoz Ltd.; US4618359; (1986); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics