With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of the compound 1-1(4.75 g, 30.03 mmol) in MeOH(60 ml) was added NH4OAc(6.95 g, 90.10 mmol). After stirring for 3 h at rt, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in DCM(300 ml). The resulting mixture was washed with water(75 ml), dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the desired product 1-2(4.72 g) as a white solid.1H NMR (300 MHz, CDC13) 5 7.6 10 (brs, 1H), 6.856 (brs, 1H), 4.126 (s, 3H), 3.647 (t, J = 5.7 Hz, 2H), 3.538 (s, 3H), 2.249 (t, J = 5.7 Hz, 2H)., 127956-11-0
As the paragraph descriping shows that 127956-11-0 is playing an increasingly important role.
Reference£º
Patent; ST PHARM CO., LTD.; KIM, Kyungjin; KIM, Uk-Il; YOON, Ji Hye; (32 pag.)WO2017/99424; (2017); A1;,
Tetrahydropyran – Wikipedia
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