101691-94-5, 4-(Iodomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of methyl 4-bromo-7-methyl-lH-indole-6-carboxylate (Intermediate 1-2, 830 mg, 3.10 mmol) in DMF (2 mL) was added sodium hydride (186 mg, 4.64 mmol) and stirred at RT for 10 minutes. 4-(Iodomethyl)tetrahydro-2H-pyran (1050 mg, 4.64 mmol) was added and stirred at 65-70 C for 16 h. After completion of the reaction, water was added and extracted with ethyl acetate. The organic layer was purified by column chromatography (silica gel, 5-8% ethyl acetate in pet ether) to obtain the title compound. Yield: 350 mg (30 %); JH NMR (CDCI3; 300 MHz): delta 7.77 (s, 1H), 7.16 (d, J = 3 Hz, 1H), 6.54 (d, J= 3.3 Hz, 1H), 4.24 (d, J= 7.2 Hz, 2H), 3.93-3.97 (m, 2H), 3.92 (s, 3H), 2.24-2.29 (m, 2H), 2.87 (s, 3H), 1.96-1.99 (m, 1H), 1.39-1.42 (m, 4H); MS (ESI+): 367.9 [M+H]+; HPLC purity: 96.71 %., 101691-94-5
As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.
Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; GUPTE, Amol; SHARMA, Rajiv; KANDRE, Shivaji; KADAM, Kishorkumar; GUHA, Tandra; DEHADE, Amol; MORE, Tulsidas; ROYCHOWDHURY, Abhijit; WO2015/104677; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics