With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.
A solution of imidazole-1-carboxylic acid cis-3= [5- (2, 2-dimethyl- propionylamino)-2H-pyrazol-3-yl]-cyclobutyl ester (200 mg) and C- (tetrahydro-pyran- 4-yl)-methylamine (83 mg) in EtOAc was stirred at 70 C overnight. After cooling, the title product was isolated by silica gel chromatography. MS (M+H) + = 379.3., 220641-87-2
The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER PRODUCTS INC.; WO2005/51919; (2005); A1;,
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