With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.
EXAMPLE 11 Preparation of 3-Tetrahydropyranyl 2-(Methylthio-5-(2-Chloro-4-trifluoromethylphenoxy)benzoate 3-Hydroxytetrahydropyran (0.04 mole), toluene (50 ml) and triethylamine (0.04 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer and addition funnel. A solution of 2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzoyl chloride (0.04 mole) in toluene (20 ml) is slowly added at room temperature with stirring. After the addition is completed, stirring is continued for a period of about eight hours. After this time, the reaction mixture is washed with water and dried over anhydrous magnesium sulfate. The dried solution is then stripped of solvent is then stripped of solvent under reduced pressure leaving a residue. This residue is purified by silica gel chromatography using toluene and ethyl acetate/toluene mixture as the eluant to yield the desired product 3-tetrahydropyranyl 2-methylthio-5-(2-chloro-4-trifluoromethylphenoxy)benzoate., 19752-84-2
The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sandoz Ltd.; US4618359; (1986); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics