With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.
85064-61-5, 0 ¡ãC lower, comprising the tetrahydropyran-4-acetic acid (86.5 mg, 0.6 mmol) of dichloromethane solution (5 ml) in, dropping of a catalytic amount of DMF 2 drop, and containing oxalyl (152.4 mg, 1.2 mmol) of dichloromethane solution; after the completion of the dropping, the reaction temperature to room temperature 3 hours, decompressing to evaporate the solvent; 0 ¡ãC lower, residue is dissolved in dichloromethane is used for, drop into the containing (3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-yl) cyclopentyl methanone (150 mg, 0.4 mmol) and triethylamine (121.2 mg, 1.2 mmol) in dichloromethane solution (5 ml) in, dropped, temperature to room temperature overnight the reaction; the majority of the solvent is removed under reduced pressure, by silica gel column chromatography and thick preparation plate purification to obtain white solid compound 20.0 mg, yield 10.2percent
85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Fudan University; Wang Yonghui; Tian Jinlong; Yu Mingcheng; (29 pag.)CN109134476; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics