With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33821-94-2,2-(3-Bromopropoxy)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
Under argon protection,Anhydrous tetrahydrofuran (100 mL) and 1-octyne (8.82 g, 80 mmol) were added to a 200 mL Schlenk reaction flask and stirred to dissolve.The mixture was cooled to -40 C, n-butyllithium (39.0 mL, 2.4 M n-hexane solution, 88 mmol) was slowly added dropwise, and the reaction was stirred for 4 h after the dropwise addition.Then, HMPA (6.83 mL, 80 mmol) was added dropwise dropwise, and the reaction was stirred for 0.5 h.1-tetrahydropyranyloxy-3-bromopropane 2 (8.92 g, 40 mmol) was added dropwise.After the addition was completed, the temperature was slowly raised to room temperature to continue the reaction for 24 hours.After completion of the reaction, the reaction was quenched with a saturated aqueous solution of ammonium chloride and the organic phase was separated.The aqueous phase was extracted with diethyl ether (3¡Á40 mL).The organic phase was washed with aq. aq.Finally purified by silica gel column chromatography (petroleum ether / ethyl acetate 30:1).Obtained a light yellow oily liquid 1-tetrahydropyranyloxy-4-undecyne 3(9.09 g, yield 90%)., 33821-94-2
33821-94-2 2-(3-Bromopropoxy)tetrahydro-2H-pyran 2777988, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; China Agricultural University; Zhong Jiangchun; Sun Xiao; Bian Qinghua; Wang Min; Zhou Yun; Yuan Gucheng; (7 pag.)CN109970534; (2019); A;,
Tetrahydropyran – Wikipedia
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