With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.,85064-61-5
S nthesis of Compound D6Step 1: Synthesis of Compound D2To a suspension of 0.55 g of LiAlH4 (13.9 mmol) in THF (10 mL) is added dropwise a solution of 2 g (13.9 mmol) of compound Dl in THF (10 mL) under nitrogen atmosphere (CAUTION: highly exothermic reaction.). Upon complete addition, the reaction is stirred at room temperature for 18 h. The reaction is cooled in an ice-bath and quenched with addition of 1M aqueous NH4C1 solution (2 mL). The resulting precipitate is removed by filtration through Celite and is rinsed with ethyl acetate (3 x 100 mL). The filtrate is dried over Na2S04, filtered and concentrated under reduced pressure to afford 1.63 g of compound D2 as a colorless oil. Yield: 90%; ES-MS m/z 131 [M+H]; 1H-NMR (500 MHz, CHLOROFORM-d) 5 ppm l.29 (2 H, qd, 7=12.08, 4.04 Hz), 1.50 (2 H, qd, 7=6.71, 1.37 Hz), 1.55 – 1.73 (3 H, m), 1.95 – 2.07 (1 H,m), 3.37 (2 H, t, 7=11.83 Hz), 3.66 (2 H, t, 7=6.03 Hz), 3.92 (2 H, dd, 7=11.44, 4.12 Hz)
As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; ZINDELL, Renee, M.; ERMANN, Monika; WO2011/109324; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics