With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693287-79-5,tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate,as a common compound, the synthetic route is as follows.
693287-79-5, B) tetrahydro-2H-pyran-4-ylhydrazine dihydrochloride [0432] tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate (1.82 g) was dissolved in 4N hydrogen chloride-ethyl acetate solution (85 mL) under ice-cooling, and the solution was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure to give the title compound (1.52 g). 1H NMR (300 MHz, CDCl3) delta 1.36-1.57 (2H, m), 1.89 (2H, dd, J = 12.5 Hz, 2.3 Hz), 3.12 (1H, tt, J = 11.0 Hz, 4.1 Hz), 3.28 (2H, td, J = 11.6 Hz, 2.1 Hz), 3.89 (2H, dt, J = 9.9 Hz, 2.0 Hz), 7.73 (3H, brs).
693287-79-5 tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate 45092245, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; NARA, Hiroshi; DAINI, Masaki; KAIEDA, Akira; KAMEI, Taku; IMAEDA, Toshihiro; KIKUCHI, Fumiaki; EP2857400; (2015); A1;,
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