116131-44-3, 3-(Bromomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
116131-44-3, A mixture of 3- Bromomethyl Tetrahydro-2H-Pyran (24.75 g 0.138 mol), DMPU (225 ml), FeCl3 (0.75 g) and CuCl (0.3 g) was slowly added Et2Zn (106.8 ml) by drop-wise at 40~45 for 45 minutes to get the zinc-reagent. To a mixture of 4-chloro-2-(4-chlorophenyl)-thieno[2,3-d]pyridzaine-7-carboxylic acid ethyl ester, THF (810 ml) and PdCl2(dppf) (5.09 g) was added zinc-reagent mentioned above at 40~45 for 4 hours. The reaction was poured into saturated brine and filtrated after stirring for 15 minutes; the aqueous fraction was washed by THF (500 ml, 2*). The organic layer and the extract were washed with saturated brine and dried over anhydrous Na2SO4 over night. The organic layer was concentrated under reduced pressure to give 2-(4-chlorophenyl)-4-(3-tetrahydropyranmethy)-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester (25 g). MS (ESI): 417 (M+1).
The synthetic route of 116131-44-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Wu, Zhanggui; US2009/275585; (2009); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics