Day: September 21, 2020

5631-96-9,5631-96-9, 2-(2-Chloroethoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 3-(3-(4-(2-hydroxyethoxy)phenyl)-2-oxoimidazolidin-1-yl)-2,6-dioxopiperidine-1- carbox late: (1580) A reaction vessel is charged with tert-butyl 3-(3-(4-hydroxyphenyl)-2-oxoimidazolidin-1- yl)-2,6-dioxopiperidine-1-carboxylate (1 equiv.), potassium carbonate (2 equiv.) and DMF (0.5 M).2-(2-Chloroethoxy)tetrahydro-2H-pyran (1.1 equiv.) is added and the reaction is heated at 110 C for 12 hours. The reaction is then cooled to ambient temperature and concentrated. The residue is taken up in water and ethyl acetate and the layers separated. The aqueous layer is extracted with ethyl acetate (2x). The combined organic layer is washed with brine, dried over sodium sulfate, filtered and concentrated. The crude residue is used directly in the following reaction.

As the paragraph descriping shows that 5631-96-9 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; CHEN, Chi-li; DUPLESSIS, Martin; HE, Minsheng; LAZARSKI, Kiel; (980 pag.)WO2017/197051; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5631-96-9,2-(2-Chloroethoxy)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

5631-96-9, General procedure: A mixture of 3 (2.64 g, 4.02 mmol), commercially available 2-(2-chloroethoxy) tetrahydro-2H-pyran (4) (0.79 g, 4.82 mmol), K2CO3 (1.11 g, 8.04 mmol) and KI (0.13 g, 0.80 mmol) in N,N-dimethylformamide (DMF) (40 mL) under argon was stirred overnight at 90C. After cooling to room temperature, themixture was diluted with CHCl3 (200 mL) and H2O (200 mL). The aqueous phase was extracted with CHCl3 (100 mL, twice), and the combined organic phases were washed with brine (50 mL), dried over MgSO4 and evaporated to give crude 5. Purification of the crude sample by column chromatography over silica gel (hexane/EtOAc) gave pure 5 (1.22 g, 39% yield).

The synthetic route of 5631-96-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hattori, Yoshiyuki; Hara, Eriko; Shingu, Yumiko; Minamiguchi, Daiki; Nakamura, Ayako; Arai, Shohei; Ohno, Hiroaki; Kawano, Kumi; Fujii, Nobutaka; Yonemochi, Etsuo; Biological and Pharmaceutical Bulletin; vol. 38; 1; (2015); p. 30 – 38;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

Step 4, dilute 3-isobutylglutaric anhydride with methyl tert-butyl ether, add 100 ml of 10% ammonia water in a 500 ml reaction flask, and cool the mixture of 3-isobutylglutaric anhydride after cooling. 80 ml of tert-butyl ether solution, the reaction was stirred at room temperature, and the organic phase was separated, and the pH was adjusted to 0.5-1 with 6 mol/L hydrochloric acid. Washing, decoloring, suction filtration, washing with water, and drying were carried out to obtain (¡À)- 3-carbamoylmethyl-5-methylhexanoic acid;, 185815-59-2

As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.

Reference£º
Patent; Anhui Dongkai Biological Technology Co., Ltd.; Liu Yaopeng; Yu Zhenyun; Zhou Zhongwei; Wan Qing; Lu Jun; Fu Xuelian; (6 pag.)CN110156732; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

29943-42-8, Dihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,29943-42-8

NaH (mass fraction 60%, 5g, 125mmol) was slowly added to tetrahydrofuran (200mL) at room temperature. After the addition was complete, tetrahydro-4H-pyran-4one (5.0g, 50mmol) and dimethyl carbonate were added. (10 mL, 125 mmol). The reaction system was heated to 60 C, and the reaction was stirred for 24 hours. After the reaction was detected to be complete by LC-MS, suction filtration was performed. After the filtrate was adjusted to neutral pH with acid, extraction was performed with diethyl ether, the liquid phase was separated, and the organic phase was dried over anhydrous sodium sulfate. The solution was concentrated by filtration and purified by silica gel column chromatography to obtain methyl 4-oxotetrahydro-2H-pyran-3-carboxylate (3.6 g, 22.8%).

As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.

Reference£º
Patent; Fujian Tuoxi New Materials Technology Co., Ltd.; Weng Songqing; (14 pag.)CN110372712; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.

STEP 2. DIHYDRO-2H-PYRAN-3(4H)-ONE To a stirred mixture of pyridinium chlorochromate (11.02 g, 51.1 mmol) and 3 A molecular sieves (10.0 g) in DCM (100 mL) was added a solution of tetrahydro-2H-pyran-3-ol (3.48 g, 34.1 mmol) in DCM (100 mL). The reaction mixture was refluxed for 3 h before being cooled to room temperature and partially concentrated in vacuo. The mixture was then diluted with EtOAc and filtered through Celite. The filtrate was concentrated in vacuo and purified by silica gel chromatography to give dihydro-2H-pyran-3(4H)-one.

19752-84-2, As the paragraph descriping shows that 19752-84-2 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; US2010/160280; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

61363-56-2, 2H-Pyran-3,5(4H,6H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61363-56-2

Compound II (22.80 g, 0.2 mol, 1.0 e.q.) was dissolved in chloroform (300 mL).PCl5 (20.82g, 0.1mol, 0.5e.q.) was added in portions at 0 C, and the reaction was stirred under reflux for 5 h. After cooling, the residue is removed by filtration, and the filtrate is concentrated and purified by sand column chromatography to obtainCompound III-2 was a yellow oily substance (20.3 g), yield 76.6%.

61363-56-2 2H-Pyran-3,5(4H,6H)-dione 325287, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing Yaoshi Technology Co., Ltd.; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Li Jilong; Fei Qinlong; Li Hui; (13 pag.)CN108558806; (2018); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.

To a solution of tetrahydro-2H-pyran-3-ol (compound 5) (51.0 mg, 0.5 mmol) in CH2Cl2 (2.5 mL) was added with Et3N (55.0 mg, 0.55 mmol) and DMAP (3 mg, 0.025 mmol), followed by the addition of cinnamoyl chloride (92.0 mg, 0.55 mmol) at 0 C. The mixture was stirred for 18 h then added with saturated NaHCO3 solution. The organic phase was separated and washed with brine, dried over anhydrous Na2SO4. The crude product was purified via silica gel column with PE/EtOAc (30:1-10:1) to give the title compound 6 as a white foam, 19752-84-2

The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Geng, Yang; Zheng, Maolin; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie; Tetrahedron Letters; vol. 58; 42; (2017); p. 3966 – 3969;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

33024-60-1, Tetrahydro-2H-pyran-4-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,33024-60-1

Example 71 (2E)-3-(1-benzhydryl-3-cyano-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-N-tetrahydro-2H-pyran-4-ylprop-2-enamide To a solution of (2E)-3-(1-benzhydryl-3-cyano-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)propenoate (300 mg, 0.759 mmol) in THF (3 ml) were added DMF (0.03 ml) and oxalylchloride (0.0796 ml, 0.912 mmol), the mixture was stirred at room temperature for 1 hour, and the solvent was distilled off under reduced pressure. The residue was added under ice-cooling to a solution of tetrahydro-2H-pyran-4-ylamine hydrochloride (184 mg, 1.51 mmol), triethylamine (0.560 ml, 4.01 mmol) and THF (3 ml), the mixture was stirred under ice-cooling for 1 hour and at room temperature for 12 hours. The reaction solution was poured into water, and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was recrystallized from hexane and ethyl acetate. Yield (amount) 173 mg, yield (rate) 46.5percent 1H-NMR (CDCl3) delta: 1.26-1.62 (2H, m), 1.84-1.90 (2H, m), 2.57 (3H, s), 2.75 (3H, s), 3.38-3.49 (2H, m), 3.92-4.10 (3H, m), 5.54 (1H, d, J = 8.2 Hz), 6.78 (1H, d, J = 15.8 Hz), 6.92 (1H, s), 7.20-7.45 (11H, m), 8.05 (1H, s). IR (KBr) cm-1; 3300, 2215, 1657, 1618, 1591, 1547, 1426, 1335, 912, 735, 698.

33024-60-1 Tetrahydro-2H-pyran-4-amine hydrochloride 44118693, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1535922; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

624734-17-4, 3-Methoxydihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

624734-17-4, Intermediate 5a; Commercially available 3-Methoxy-tetrahydro-pyran-4-one (1 g, 7.68 mmol), commercially available (R)-(+)-l-phenylethylamine (0.99 ml, 7.68 mmol) and Raney-Nickel (200 mg) in 10 ml of dry ethanol were stirred under a hydrogen atmosphere (5 bar) for 15 days. The reaction mixture was diluted with 20 ml of methanol and 20 ml of tetrahydroiurane, stirred for 15 minutes, filtered on a celite pad and concentrated under vacuum. The crude product was loaded on a SCX cartridge (50g). The cartridge was washed with methanol and the desired product was eluted with a 7 M solution of ammonia in methanol. The basic organic phase was concentrated under vacuum and the crude product was purified by flash chromatography (dichloromethane/methanol= 98/2%) to obtain 710 mg (3.02 mmol) of the desired product as single stereoisomer (diastereoisomeric purity confirmed and relative cis stereochemistry assigned by NMR). GC/MS (method 3B) Rt = 35.04 min

As the paragraph descriping shows that 624734-17-4 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; MAZZAFERRO, Rocco; SCHEUERER, Stefan; WO2011/141477; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

61363-56-2, 2H-Pyran-3,5(4H,6H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To compound 34 (200 mg, 1.8 mmol, 1.0 eq) was added benzylamine (169 mg, 1.6 mmol, 0.9 eq) in 2 mL of dichloromethane and MeOH (200 tL) in one portion at 25C under N2. The mixture was stirred at 25C for 5 hours.The reaction was monitored by TLC and allowed to run until complete. The reaction mixture was concentrated under reduced pressure to remove solvent to afford 350 mg of the crude product 3-(benzylamino)-2H-pyran-5-one 35 as yellow oil., 61363-56-2

The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics