With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.
To a solution of tetrahydro-2H-pyran-3-ol (compound 5) (51.0 mg, 0.5 mmol) in CH2Cl2 (2.5 mL) was added with Et3N (55.0 mg, 0.55 mmol) and DMAP (3 mg, 0.025 mmol), followed by the addition of cinnamoyl chloride (92.0 mg, 0.55 mmol) at 0 C. The mixture was stirred for 18 h then added with saturated NaHCO3 solution. The organic phase was separated and washed with brine, dried over anhydrous Na2SO4. The crude product was purified via silica gel column with PE/EtOAc (30:1-10:1) to give the title compound 6 as a white foam, 19752-84-2
The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Geng, Yang; Zheng, Maolin; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie; Tetrahedron Letters; vol. 58; 42; (2017); p. 3966 – 3969;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics