14774-36-8, (Tetrahydropyran-3-yl)methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 85: Tetrahydro-2H-pyran-3-ylmethyl methanesulfonateTo tetrahydro-2H-pyran-3-ylmethanol (4.92g) in dry dichloromethane (140 ml) at O0C and under nitrogen, was added anhydrous triethylamine (13.6 ml) in one go, followed by mesyl chloride (4.3 ml) dropwise over 5 minutes. The reaction was allowed to warm to room temperature and stirred at this temperature overnight. The reaction was quenched with saturated aqueous sodium bicarbonate (50 ml). The organic layer was separated, passed through a hydrophobic frit to dry and concentrated in vacuo to yield a red oil (8.8 g).1H NMR (CDCI3): delta 4.18-4.08 (2H, m), 3.94-3.88 (1 H, m), 3.81 (1 H, m), 3.51-3.43 (1 H, m), 3.37-3.31 (1 H, m), 3.01 (3H, s), 2.07 (1 H, m), 1.85 (1 H, m), 1.72-1.56 (2H, m), 1.47-1.36 (1 H, m).
14774-36-8, The synthetic route of 14774-36-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/101867; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics