1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2-((lH-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4- chlorophenyl)-2-oxaspiro[3.5]non-6-en-7-yl)methyl)piperazin-l-yl)benzoic acid (250 mg, 0.43 mmol), 3-nitro-4-(((tetrahydro-2H-pyran-4- yl)methyl)amino)benzenesulfonamide (202 mg, 0.64 mmol), EDCI (164 mg, 0.86 mmol), 4-(N,N-dimethylamino)pyridine (78 mg, 0.64 mmol) in dichloromethane (10 ml) was stirred at room temperature for overnight, followed by concentration. The resulting residue was purified through silica gel column to afford 2-((lH-pyrrolo[2,3- b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)-2-oxaspiro[3.5]non-6-en-7-yl)methyl) piperazin-l-yl)-N-((3-nitro-4-(((tetrahycko-2H-pyran-4-yl)methyl)amino)phenyl) sulfonyl) benzamide (150 mg, 39.6 %) as yellow solid. *H NMR (400 MHz, Methanol-^) delta 8.70 (d, / = 2.3 Hz, 1H), 8.01 (d, / = 2.6 Hz, 1H), 7.87 (dd, / = 9.2, 2.3 Hz, 1H), 7.66 (d, / = 8.8 Hz, 1H), 7.56 (d, / = 2.6 Hz, 1H), 7.47 (d, / = 3.5 Hz, 1H), 7.39 (d, / = 8.4 Hz, 2H), 7.13 (d, / = 8.4 Hz, 2H), 6.97 (d, / = 9.2 Hz, 1H), 6.76 (dd, / = 8.8, 2.4 Hz, 1H), 6.43 (d, / = 3.5 Hz, 1H), 6.32 (d, / = 2.4 Hz, 1H), 4.54 (d, / = 5.9 Hz, 2H), 4.48 (d, / = 5.9 Hz, 2H), 4.03 – 3.94 (m, 2H), 3.67 (s, 2H), 3.55 – 3.27 (m, 12H), 2.69 (s, 2H), 2.35 – 2.25 (m, 2H), 2.08 (t, / = 6.3 Hz, 2H), 2.05 – 1.93 (m, 1H), 1.76-1.69 (m, 2H), 1.45 – 1.35 (m, 2H).
1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Chia, Wei; CHEN, Jianyong; (131 pag.)WO2018/27097; (2018); A1;,
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