25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4-bromotetrahydro-2H-pyran (50.0 g, 303 mmol, 1.0 eq) in DMF (300 mL) under a N2 atmosphere was added KSAc (41.5 g, 364 mmol, 1.2 eq) and the mixture was stirred at RT overnight. The mixture was diluted with water (700 mL) and extracted with EtOAc (200 mL*3). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to afford the title compound (41.5 g, 68%) as a brown oil. 1H NMR (400 MHz, CDCl3) delta 3.91-3.87 (m, 2H), 3.71-3.64 (m, 1H), 3.57-3.51 (m, 2H), 2.31 (s, 3H), 1.92-1.88 (m, 2H), 1.71-1.62 (m, 2H)., 25637-16-5
As the paragraph descriping shows that 25637-16-5 is playing an increasingly important role.
Reference£º
Patent; Ribon Therapeutics Inc.; Schenkel, Laurie B.; Vasbinder, Melissa Marie; Kuntz, Kevin Wayne; Swinger, Kerren Kalai; (179 pag.)US2019/194174; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics