With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.
To a solution of dimethyl carbonate (22.50 g, 249.78 mmol, 5.00 equiv) in tetrahydrofuran (70 ml_) at 0 C was added sodium hydride (6.00 g, 150.00 mmol, 3.00 equiv, 60%). The mixture was stirred at 15 C for 1 h and then the mixture was cooled to 0 C and oxan-4-one (5.00 g, 49.940 mmol, 1.00 equiv) was added dropwise. The resulting solution was stirred for 2 h at 60 C in an oil bath. The reaction was then quenched by the addition of water and the pH adjusted to 6 with hydrogen chloride (2N). The resulting solution was extracted with ethyl acetate (3×20 ml_) and the organic layers combined and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (10/90). The collected fractions were combined and concentrated under vacuum to yield methyl 4-oxooxane-3- carboxylate as yellow oil.
29943-42-8, 29943-42-8 Dihydro-2H-pyran-4(3H)-one 121599, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; LANTER, James C.; WALL, Mark; SUI, Zhihua; (0 pag.)WO2019/171278; (2019); A1;,
Tetrahydropyran – Wikipedia
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