1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1194-16-7, A) 4-(methoxymethylene)-2,2-dimethyltetrahydro-2H-pyran Thereto was added (methoxymethyl)triphenylphosphonium chloride (17.0 g), and the mixture was dried under reduced pressure at 100C for 1 hr. Under a nitrogen atmosphere, dehydrated THF (80 mL) was added, and potassium tert-butoxide (5.40 g) was further added at -30C. After 40 min, to the reaction mixture was added dropwise a solution of 2,2-dimethyltetrahydropyran-4-one (5.20 g) in dehydrated THF (5.0 mL) over 15 min, and the mixture was stirred at room temperature for 4 hr. To the reaction mixture was added aqueous ammonium chloride solution, and the mixture was extracted with diethyl ether. The extract was washed with saturated brine, and dried. The solvent was evaporated, and the residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give an isomer mixture (E:Z = 1:1, 4.00 g) of the title compound as a colorless transparent oil. 1H NMR(400 MHz, CDCl3) delta 1.18 (6H, s), 1.20 (6H, s), 1.92 (2H, d, J = 1.2 Hz), 1.98-2.02 (2H, m), 2.17 (2H, d, J = 0.8 Hz), 2.23-2.26 (2H, m), 3.54 (3H, s), 3.56 (3H, s), 3.64-3.70 (4H, m), 5.77-5.78 (1H, m), 5.92-5.93 (1H, m).
1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; MIWATASHI, Seiji; SUZUKI, Hideo; OKAWA, Tomohiro; MIYAMOTO, Yasufumi; YAMASAKI, Takeshi; HITOMI, Yuko; HIRATA, Yasuhiro; EP2816032; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics