1768-64-5, 4-Chlorotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a suspension of Mg (1.37 g, 56.5 mmol) and I2(10 mg) in THF (2 mL) was added a solution of 4-chlorotetrahydro-2H-pyran (2.72 g, 22.6 mmol) in THF (8 mL) at 60C drop wise. The mixture was stirred at 60C for 2 h. The mixture was diluted with THF (10 mL) and used directly. The Grignard reagent was added to a solution of G-6 (0.55 g, 1.28 mmol) in THF (5 mL) at 0C. The mixture was stirred at 0C for 1 h and treated with NH4C1 (10 mL, sat. aq.). The mixture was extracted with EtOAc (3 x 20 mL). The organic layer was separated, concentrated in vacuum, purified by silica gel column (PE/EtOAc=20/l to 5/1) to give a crude product, which was re-crystallized from CH3CN (10 mL) to give Compound 9 (180 mg, 27%) as a solid.1H NMR (400 MHz, CDC13) delta 4.05-3.97 (m, 2H), 3.41-3.25 (m, 3H), 2.10-1.91 (m, 3H), 1.88- 1.57 (m, 7H), 1.55-1.33 (m, 11H), 1.33-0.96 (m, 12H), 0.96-0.86 (m, 4H), 0.85 (s, 3H), 0.72- 0.63 (m, 4H).HPLC Rt = 4.73 min in 8.0 min chromatography, 50-100 AB.MS ESI calcd. for C30H48F3O2[M+H-H20]+497, found 497., 1768-64-5
As the paragraph descriping shows that 1768-64-5 is playing an increasingly important role.
Reference£º
Patent; SAGE THERAPEUTICS, INC.; SALITURO, Francesco G.; ROBICHAUD, Albert J.; MARTINEZ BOTELLA, Gabriel; HARRISON, Boyd L.; GRIFFIN, Andrew; LA, Daniel; (387 pag.)WO2018/75699; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics