14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To the stirred solution of tetrahydropyran-4-ylmethanol 10-1 (200 mg, 1.72 mmol) in DCM (5 rnL) was added TEA (348.46 mg, 3.44 mmol, 479.97 uL) followed by methanesulfonyl chloride 10-2 (236.68 mg, 2.07 mmol, 159.92 uL). The reaction was stirred at room temperature for 5 hours and the cooled to room temperature, diluted with ethyl acetate, washed with water, brine, dried over sodium sulfate and concentrated under reduced pressure to afford tetrahydropyran-4-ylmethyl methanesulfonate 10-3 (328 mg, 1.69 mmol, 98.07% yield) as gum. 1HNMR (400 MHz, DMSO- d6) 5 4.1-4.0 (m, 2H), 3.85 (dd, J = 11.28, 3.96 Hz, 2H), 3.34-3.26 (m, 2H), 3.17(s, 3H), 1.98-1.88 (m, I I I), 1.60-1.55 (m, 2H), 1.31-1.20 (m, 21 1), 14774-37-9
The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; C4 THERAPEUTICS, INC.; VEITS, Gesine, Kerstin; HE, Minsheng; HENDERSON, James, A.; NASVESCHUK, Christopher, G.; PHILLIPS, Andrew, J.; GOOD, Andrew, Charles; (471 pag.)WO2019/191112; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics