185815-59-2, 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A three-necked flask equipped with an addition funnel, thermometer pocket, drying tube and a mechanical stirrer, was charged with toluene (400 ml), (S)-(-)-phenylethylamine(142.35 g,1.1764 mole), and 4-dimethylaminopyridine (0.7176 g, 0.0059 mole). The mixture was cooled to a temperature of -10C to -15C, followed by addition of a solution of 3-isobutyl glutaric anhydride (100 g, 0.59 mole) [e.g. obtained in accordance with the process disclosed Drugs of the Future, 24 (8), 862-870 (1999) or according to Example 1 step (A) above] in toluene (100 ml), over a period of 45-60 minutes, and stirring for additional 1.5-2 hours, at a temperature of -10C to -15C. The mixture was then extracted with 10% aqueous solution of NaOH (500 ml), and the aqueous phase was washed with toluene (1×250 ml). The pH of the aqueous phase was adjusted to 2-2.5 by adding a solution of hydrochloric acid (1-12N). The aqueous phase was further extracted with toluene (1x 800 ml) at a temperature of 70-80C. The toluene layer was washed with 10% sodium chloride solution {700ml) at a temperature of 70-80C followed by crystallization to get 125 g (73.0% yield) of a white solid of (3S)-5-methyl-3-(2-oxo-2-{[(1S)-1-phenylethyljamino}ethyl) hexanoic acid with an optical purity of 99.75 %, as measured by chiral HPLC., 185815-59-2
As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.
Reference£º
Patent; TEVA PHARMACEUTICALS INTERNATIONAL GMBH; JANAGANI, Satyanarayana; (38 pag.)WO2017/19791; (2017); A1;,
Tetrahydropyran – Wikipedia
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