With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.
To a solution of tetrahydro-2H-pyran-4-ol (4 mL, 41.11 mmol) in DCM (60 mL) was added TEA (9 mL, 63.9 mmol) at 0. After stirring 5 min, methanesulfonyl chloride (3.5 mL, 45 mmol) was added slowly to the mixture. The resulting mixture was stirred for 1 h and warmed to rt, and then further stirred overnight. The reaction mixture was diluted with water (50 mL) . The resulting mixture was extracted with DCM (100 mL ¡Á 3) . The combined organic layers were dried over anhydrous Na2SO4and concentrated in vacuo to give a light yellow solid product (7 g, 94.5) .[1586]MS (ESI, pos. ion) m/z: no response.
2081-44-9, 2081-44-9 Tetrahydro-2H-pyran-4-ol 74956, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHANG, Yingjun; CHENG, Changchung; HUANG, Jiuzhong; BAI, Shun; REN, Xingye; LI, Zhi; ZHOU, Youbai; (368 pag.)WO2016/615; (2016); A1;,
Tetrahydropyran – Wikipedia
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