Brief introduction of 101691-65-0

101691-65-0, As the paragraph descriping shows that 101691-65-0 is playing an increasingly important role.

101691-65-0, (Tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step B: 1 -(Tetrahvdropyran-4-yl)methyl-7-chloro-1 /-/-indole-3-carboxylic acid To a solution of 7-chloro-1 /-/-indole-3-carboxylic acid (7.5 g, 38.0 mmol) in di- methylformamide (100 ml) at 10 C under nitrogen was added sodium hydride (60% dispersion in mineral oil, 3.1 g, 76.0 mmol) portionwise over 10 mins, maintaining the temperature below 15 C. The cooling bath was removed and the suspension stirred for 90 mins. Toluene-4-sulfonic acid tetrahydopyran-4-ylmethylester (14.6 g, 53.0 mmol) was added. The mixture was heated at 50 C with stirring for 6 h. Dimethylformamide was removed by evaporation and the residue was dissolved in water (500 ml). The emulsion was washed with dichloromethane (2 x 100 ml). The aqueous phase was acidified to pH 1 using 5 M hydrochloric acid and the precipitate filtered off, washed with water to neutrality and dried to afford 1-(tetrahydropyran-4- yl)methyl-7-chloro-1 /-/-indole-3-carboxylic acid (15.0 g, 51.0 mmol) as a white solid.

101691-65-0, As the paragraph descriping shows that 101691-65-0 is playing an increasingly important role.

Reference£º
Patent; AKZO NOBEL N.V.; WO2007/23143; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics