With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
Example 1; Preparation of Fenchyl Ester; A three-neck-flask (0.25 l) was charged with toluene (140 ml), Fenchyl alcohol (9.26 g) and NaH-60% (2.4 g). The mixture was heated to 80 C., and then cooled to 5 C. A solution of 3-isobutyl glutaric anhydride (6.8 g) in toluene (25 ml) was added to the mixture dropwise. The solution was stirred for 3 hours at room temperature. The solvent was evaporated to dryness to obtain the crude ester. The solid was dried at 55 C. under vacuum. Example 2; Isolation of (S), (R)-Fenchyl Ester; The crude ester prepared in example 1, is added to a mixture of ethyl acetate and toluene, and heated to 80 C. (range 400 to 100 C.) until dissolution. The solution is cooled to 2 C. (range 0 to 20 C.) to get a yellowish solid of (S)-3-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)carbonyl)methyl)-5-methylhexanoic acid (Fenchyl ester), which is filtered from the mixture.
185815-59-2, As the paragraph descriping shows that 185815-59-2 is playing an increasingly important role.
Reference£º
Patent; Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; US2007/293694; (2007); A1;,
Tetrahydropyran – Wikipedia
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