With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
Example 19; Asymmetric Ring Opening of IBG-Anhydride with Chiral Alkaloide; Methanol (6.2 ml, 153 mmol) was added drop-wise to a 250 ml three-necked, round-bottomed flask equipped with magnetic stirrer and charged with Quinine (7.14 g, 22 mmol), 3-isobutyl glutaric anhydride (3.28 g, 19.3 mmol) and Toluene (100 ml, 30 vol) at -70 C. The reaction was stirred for 17 hours. The solution was concentrated to dryness, and the resulting residue was dissolved in diethyl ether (125 ml). The solution was washed with HCl-2N (40 ml¡Á3). The organic layer was evaporated until dryness, to have 3.7 g yellow oil of R-Hemiester (Optical purity 80%, Yield -95%).
185815-59-2, The synthetic route of 185815-59-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; US2007/293694; (2007); A1;,
Tetrahydropyran – Wikipedia
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