1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: To a solution of 2 , 2-dimethyldlhydro-2if-pyran~4 (3H) -one (1.00 g, 7.80 mmol) in toluene (6 mL) was added lithium bis ftrimethylsilyl) amide (1 M in THF, 8.19 mL, 8.19 mmol) at 0 C. The mixture was stirred for 2 minutes followed by addition of ethyl 2-chloro-2-oxoacetate (1.06 g, 7.80 mmol). The mixture was stirred at 0 C for 5 minutes followed by addition of HOAc (0.64 mL) in H20 (8 mL) . The organic layer was separated, dried over Na2S04, filtered, and concentrated under reduced pressure. The residue was chromatographed over silica gel (0-40% EtOAc in hexanes) to give a yellow oil. The material was dissolved in EtOH (10 mL) . Methylhydrazine (0.103 mg, 2.23 mmol) was added. The solution was heated at 75 C for 1.5 h, cooled to ambient temperature and concentrated. The residue was chromatographed over silica gel (0-40% EtOAc in hexanes) to give ethyl 1 , 6 , 6-trimethyl-l , 4 , 6 , 7- tetrahydropyrano[4, 3-c]pyrazole-3-carboxylate as a thick oil (0.135 g, 38%): NMR (300 MHz, CDClj) 5 4.80 (s, 2H) , 4.32 (q, J = 7.1 Hz, 2H) , 4.14 (s, 3H), 2.63 (s, 2H) , 1.36 (t, J = 7.1 Hz, 3H) , 1.30 (s, 6H) ; MS (ESI+) /z 239 [ +H]*., 1194-16-7
As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.
Reference£º
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; PETRUKHIN, Konstantin; CIOFFI, Christopher; JOHNSON, Graham; DOBRI, Nicoleta; FREEMAN, Emily; CHEN, Ping; CONLON, Michael; ZHU, Lei; WO2014/152013; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics