873397-34-3,873397-34-3, Tetrahydro-2H-pyran-3-carboxylic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Triethylamine (5.36 g, 53.01 mmol), N-methoxy methylamine hydrochloride (1.8 g, 19.44 mmol) and HBTU (7.37g, 19.44mmol) were added in a solution of tetrahydropyran-3-carboxylic acid (2.3 g, 17.67 mmol) in DMF (25 mL), and the mixture was stirred overnight at room temperature. The reaction solution was diluted with water (100 mL) and extracted with ethyl acetate (50 mL * 5). The combined organic layers were washed with water (10 mL * 4) and saturated brine (20 mL), dried over anhydrous sodium sulfate, filtered and evaporated. The residue was purified by column chromatography to give the title compound as a colorless liquid (2.6 g, yield of 84.95percent). 1H NMR (400MHz, CHLOROFORM-d) delta = 4.05 – 3.91 (m, 2H), 3.73 (s, 3H), 3.55 – 3.37 (m, 2H), 3.18 (s, 3H), 3.02 (br d, J=11.5 Hz, 1H), 1.99 – 1.92 (m, 1H), 1.86 – 1.67 (m, 3H).
As the paragraph descriping shows that 873397-34-3 is playing an increasingly important role.
Reference£º
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; LIU, Shilan; WANG, Dahai; LIANG, Guibai; HU, Guoping; LI, Jian; CHEN, Shuhui; (167 pag.)EP3418282; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics